Gene: PTPRD

5789
HPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTA
protein tyrosine phosphatase, receptor type D
protein-coding
9p24.1-p23
Ensembl:ENSG00000153707 MIM:601598 Vega:OTTHUMG00000021005 UniprotKB:P23468
NG_033963.1
PubMed|SNP Mapped
7   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.499e-1 (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2475335chr9:10260263 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4741020chr9:10247217 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2209192chr9:9862171 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12002381chr9:8870553 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2117099chr9:8847233 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7026937chr9:8558331 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12001948chr9:8320837 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLASP20.95
PEX5L0.945
HECW20.945
DNM30.944
DNAJC60.937
PRUNE20.937
SLC24A20.937
ANK30.937
LPGAT10.935
MFSD60.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.476
PDZK1IP1-0.469
RNF135-0.468
GJB2-0.463
RHOD-0.456
MTRNR2L10-0.455
CSAG1-0.453
OR4F29-0.449
MTRNR2L8-0.444
EVC2-0.438

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PTPRD mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of PTPRD mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PTPRD mRNA"20959002
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PTPRD mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PTPRD mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PTPRD mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PTPRD mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRD mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PTPRD mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRD mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRD mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PTPRD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTPRD gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PTPRD mRNA19770486
D000393Air PollutantsPTPRD gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]27281273
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PTPRD mRNA28522335
D001280AtrazineAtrazine results in decreased expression of PTPRD mRNA25929836
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of PTPRD mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRD mRNA15034205|1977048
C006780bisphenol Abisphenol A results in decreased expression of PTPRD mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PTPRD mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PTPRD mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PTPRD mRNA27339419
C054133casticincasticin results in decreased expression of PTPRD mRNA28444820
D002737ChloropreneChloroprene results in increased expression of PTPRD mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRD mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRD mRNA17585979
D002994ClofibrateClofibrate results in increased expression of PTPRD mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRD mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRD mRNA17602206
C015763cumenecumene results in decreased expression of PTPRD mRNA18648096
D016572CyclosporineCyclosporine results in decreased expression of PTPRD mRNA19770486
D003907DexamethasoneDexamethasone results in increased expression of PTPRD mRNA22733784
D003976DiazinonDiazinon results in increased expression of PTPRD mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTPRD mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PTPRD mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of PTPRD mRNA25016146
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in decreased expression of PTPRD mRNA20665664
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRD mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of PTPRD mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PTPRD mRNA19638242
D002117CalcitriolCalcitriol results in decreased expression of PTPRD mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PTPRD mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PTPRD mRNA25380136
D004317DoxorubicinDoxorubicin results in decreased expression of PTPRD mRNA19277126
D000431EthanolEthanol results in decreased expression of PTPRD mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PTPRD mRNA12655037|1557682
C024565ethylene dichlorideethylene dichloride results in decreased expression of PTPRD mRNA28189721
D005485FlutamideFlutamide results in decreased expression of PTPRD mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRD mRNA20938992
C039281furanfuran results in decreased expression of PTPRD mRNA26194646
C001277geldanamycingeldanamycin results in increased expression of PTPRD mRNA26705709
C010176halofuginonehalofuginone results in decreased expression of PTPRD mRNA17180598
C010178heliotrineheliotrine results in decreased expression of PTPRD mRNA26100227
D017313FenretinideFenretinide results in decreased expression of PTPRD mRNA28973697
C051890irinotecanirinotecan metabolite results in increased expression of PTPRD mRNA15956246
C051890irinotecanirinotecan results in increased expression of PTPRD mRNA15956246
D007545IsoproterenolIsoproterenol results in decreased expression of PTPRD mRNA21335049
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRD mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTPRD mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PTPRD mRNA"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PTPRD mRNA22401849
D009151Mustard GasMustard Gas affects the expression of PTPRD mRNA15651846
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of PTPRD mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PTPRD mRNA19812364
C051752nefazodonenefazodone results in decreased expression of PTPRD mRNA24136188
D009532NickelNickel results in decreased expression of PTPRD mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of PTPRD mRNA24136188
C558013NSC 689534NSC 689534 results in increased expression of PTPRD mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of PTPRD mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PTPRD mRNA25729387
D052638Particulate MatterPTPRD gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]27281273
D010416PentachlorophenolPentachlorophenol results in decreased expression of PTPRD mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PTPRD mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PTPRD mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PTPRD mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of PTPRD mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PTPRD mRNA16940010
C006253pirinixic acidpirinixic acid results in decreased expression of PTPRD mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PTPRD mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PTPRD mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of PTPRD mRNA21278054
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of PTPRD mRNA26100227
D012402RotenoneRotenone results in increased expression of PTPRD mRNA19013527
C009237senecioninesenecionine results in decreased expression of PTPRD mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of PTPRD mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PTPRD mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of PTPRD gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of PTPRD mRNA25993096
D053260SootSoot results in decreased expression of PTPRD mRNA26551751
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in decreased expression of PTPRD mRNA20665664
C004648testosterone enanthatetestosterone enanthate affects the expression of PTPRD mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRD mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRD mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRD mRNA16054898|1879615
D019284ThapsigarginThapsigargin results in increased expression of PTPRD protein24648495
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of PTPRD mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of PTPRD mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of PTPRD mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PTPRD mRNA28111298
D014050TolueneToluene results in increased expression of PTPRD mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of PTPRD mRNA25729387
D019772TopotecanTopotecan results in increased expression of PTPRD mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PTPRD mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRD mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PTPRD mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PTPRD mRNA19042947
C406224valdecoxibvaldecoxib results in decreased expression of PTPRD mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRD mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PTPRD mRNA23527032|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of PTPRD gene29154799
D014635Valproic AcidValproic Acid affects the expression of PTPRD mRNA17963808
D014640VancomycinVancomycin results in increased expression of PTPRD mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTPRD gene25560391
C025643vinclozolinvinclozolin affects the expression of PTPRD mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of PTPRD mRNA20566332
D014810Vitamin EVitamin E results in decreased expression of PTPRD mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PTPRD mRNA27188386
D015032ZincZinc results in increased expression of PTPRD mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of PTPRD mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-TAS7896816  
GO:0005102signaling receptor binding-ISS-  
GO:0005515protein binding-IPI12570871  22305495  
GO:0050839cell adhesion molecule binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-TAS7896816  
GO:0006796phosphate-containing compound metabolic process-NAS7896816  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-ISS-  
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway-TAS7896816  
GO:0030182neuron differentiation-ISS-  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0050775positive regulation of dendrite morphogenesis-ISS-  
GO:0051965positive regulation of synapse assembly-ISS-  
GO:0097105presynaptic membrane assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7896816  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-388844Receptor-type tyrosine-protein phosphatasesTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis
18948947Somatic mutations affect key pathways in lung adenocarcinoma. (2008 Oct 23)Ding LNature
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One