Gene: RGS7

6000
-
regulator of G protein signaling 7
protein-coding
1q43|1q23.1
Ensembl:ENSG00000182901 MIM:602517 Vega:OTTHUMG00000040107 UniprotKB:P49802
NC_000001.11
PubMed|SNP Mapped
2   ANCO-SNPs
CD|ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.803e-1 (AD)  2.460e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10158567chr1:241125210 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12086317chr1:241100916 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAL20.971
RBFOX10.968
NSF0.966
KCNIP40.965
PAK10.96
CRYM0.959
WASF10.958
RTN10.957
SLC12A50.957
NGEF0.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.518
CSAG1-0.516
RAI14-0.515
HEY2-0.512
CNN2-0.51
REST-0.502
YES1-0.498
WWTR1-0.491
RUNX3-0.486
TFPI2-0.482

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of RGS7 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RGS7 mRNA26690555
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]"19304867
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]"19304867
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS7 mRNA16483693
D001151ArsenicArsenic affects the methylation of RGS7 gene25304211
D004958EstradiolEstradiol results in decreased expression of RGS7 mRNA20068009
C006780bisphenol Abisphenol A results in decreased expression of RGS7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RGS7 gene28505145
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of RGS7 mRNA26272509
D003024Clozapine"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
D003024Clozapine[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein18976543
D003024ClozapineClozapine results in increased expression of RGS7 mRNA18976543
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of RGS7 mRNA20971185
D003300CopperCopper deficiency results in increased expression of RGS7 mRNA26033743
D003474CurcuminCurcumin results in decreased expression of RGS7 mRNA17999991
C009160cyclonitecyclonite results in decreased expression of RGS7 mRNA25559034
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RGS7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RGS7 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of RGS7 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of RGS7 mRNA26033743
C118739entinostatentinostat results in decreased expression of RGS7 mRNA27188386
D017313FenretinideFenretinide results in increased expression of RGS7 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RGS7 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of RGS7 mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of RGS7 mRNA16807920
D007854LeadLead affects the expression of RGS7 mRNA28903495
C042720mercuric bromidemercuric bromide results in increased expression of RGS7 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of RGS7 mRNA24449571
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RGS7 mRNA22401849
C523799MRK 003RGS7 results in increased susceptibility to MRK 00319903844
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of RGS7 mRNA20971185
C076029olanzapine"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]"19304867
C076029olanzapine"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]"19304867
C076029olanzapine[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein18976543
C076029olanzapineolanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]18976543
C076029olanzapineolanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]18976543|1897654
C076029olanzapineolanzapine results in increased expression of RGS7 mRNA18976543|1930486
C076029olanzapineolanzapine results in increased expression of RGS7 protein19304867
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RGS7 mRNA26272509
D059808PolyphenolsPolyphenols results in decreased expression of RGS7 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RGS7 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of RGS7 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of RGS7 mRNA15309432
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RGS7 mRNA23806026
D014212TretinoinTretinoin results in decreased expression of RGS7 mRNA20530235
C012589trichostatin Atrichostatin A results in increased expression of RGS7 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS7 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of RGS7 mRNA23179753|2438349
C079049volinanserin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"18976543
C079049volinanserin[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein18976543
C079049volinanserinvolinanserin results in increased expression of RGS7 mRNA18976543

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA10521509  
GO:0031681G-protein beta-subunit binding-IPI19376773  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IDA10521509  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA10521509  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-390466Chaperonin-mediated protein foldingTAS
R-HSA-391251Protein foldingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20430014Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. (2010 Jun 22)Ho AMBrain Res
14534355A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. (2003 Dec)Carrasco GAJ Pharmacol Exp Ther
27533483Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population. (2017 Jan)Postula MPlatelets