Gene: SGCD

6444
35DAG|CMD1L|DAGD|SG-delta|SGCDP|SGD
sarcoglycan delta
protein-coding
5q33.2-q33.3
Ensembl:ENSG00000170624 MIM:601411 Vega:OTTHUMG00000163445 UniprotKB:Q92629
NG_008693.2
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.007e-1 (AD)  2.825e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs157672chr5:156713071 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10515737chr5:156595519 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10515739chr5:156590621 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17053572chr5:156467487 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERLIN20.756
SOX50.729
SOX60.729
NADK20.728
KDM1B0.718
SSPN0.715
CYP4V20.713
EPB41L50.712
DOCK70.711
TMEM470.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.383
OR4F29-0.332
LIPH-0.296
WFIKKN1-0.286
HRG-0.27
NPW-0.264
RHO-0.256
LAIR2-0.253
F12-0.246
CLPSL1-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of SGCD mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of SGCD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SGCD gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SGCD mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of SGCD mRNA26705709
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SGCD mRNA15894712
C015001arsenitearsenite results in increased expression of SGCD mRNA15894712
C547126AZM551248AZM551248 results in increased expression of SGCD mRNA22323515
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SGCD mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SGCD mRNA15894712
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SGCD mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of SGCD mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of SGCD mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SGCD gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGCD mRNA20147733
C018475butyraldehydebutyraldehyde results in decreased expression of SGCD mRNA26079696
D002104CadmiumCadmium results in increased expression of SGCD mRNA21120746
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of SGCD mRNA19524605
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SGCD mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SGCD mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SGCD mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of SGCD mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of SGCD mRNA26485663
D004280DobutamineSGCD affects the susceptibility to Dobutamine20675662
C118739entinostatentinostat results in decreased expression of SGCD mRNA27188386
D017313FenretinideFenretinide results in decreased expression of SGCD mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SGCD mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SGCD mRNA24796395
D008790MetoprololSGCD affects the susceptibility to Metoprolol20675662
D009532NickelNickel results in decreased expression of SGCD mRNA24768652|2558310
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of SGCD mRNA19095052
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SGCD mRNA20660070
D012969Sodium FluorideSodium Fluoride results in decreased expression of SGCD mRNA27862939
D053260SootSoot results in increased expression of SGCD mRNA26551751
D014212TretinoinTretinoin results in increased expression of SGCD mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of SGCD mRNA26705709
D014635Valproic AcidValproic Acid results in decreased methylation of SGCD gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SGCD gene25560391
D015032ZincZinc deficiency results in increased expression of SGCD mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10629222  
GO ID GO Term Qualifier Evidence PubMed
GO:0007517muscle organ development-TAS8841194  8842738  
GO:0060047heart contraction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-TAS8842738  
GO:0016010dystrophin-associated glycoprotein complex-IDA17993586  
GO:0016012sarcoglycan complex-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0042383sarcolemma-IBA21873635  
KEGG ID KEGG Term
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal