Gene: WNK1

65125
HSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65
WNK lysine deficient protein kinase 1
protein-coding
12p13.33
Ensembl:ENSG00000060237 MIM:605232 Vega:OTTHUMG00000090321 UniprotKB:Q9H4A3
NG_007984.3
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.703e-1 (AD)  2.035e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7963376chr12:817082 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10774464chr12:813242 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02736016chr12:1017144WNK11.100e-17Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD400.955
MAP4K40.947
ZEB20.936
DYNC1LI20.934
GAB20.932
HIPK20.927
MAP40.923
SMARCC10.912
ZNF6640.91
PTP4A20.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.513
OR4F5-0.429
PRTN3-0.35
CHRNA2-0.337
PCDH8-0.332
SHISA8-0.323
KCNK3-0.32
POU3F1-0.32
ASB2-0.318
TCERG1L-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of WNK1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WNK1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of WNK1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WNK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of WNK1 mRNA29067470
D000086AcetazolamideAcetazolamide results in increased expression of WNK1 mRNA19274763
D020106AcrylamideAcrylamide results in decreased expression of WNK1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of WNK1 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of WNK1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WNK1 mRNA16483693
D001151ArsenicArsenic affects the methylation of WNK1 gene25304211
D001151ArsenicArsenic results in decreased expression of WNK1 mRNA19654921
D001280AtrazineAtrazine results in decreased expression of WNK1 mRNA25929836
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of WNK1 mRNA26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WNK1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WNK1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WNK1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of WNK1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WNK1 mRNA28628672
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of WNK1 gene20938992
D016572CyclosporineCyclosporine results in decreased expression of WNK1 mRNA21865292
D016572CyclosporineCyclosporine results in decreased expression of WNK1 mRNA alternative form21865292
D003703DemecolcineDemecolcine results in increased expression of WNK1 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WNK1 mRNA28628672
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of WNK1 mRNA26271895
D002945CisplatinCisplatin results in decreased expression of WNK1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of WNK1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of WNK1 mRNA25016146
D004237DiuronDiuron results in decreased expression of WNK1 mRNA25152437
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of WNK1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of WNK1 mRNA17557909
D005485FlutamideFlutamide results in increased expression of WNK1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of WNK1 gene20938992
D005839GentamicinsGentamicins results in decreased expression of WNK1 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of WNK1 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WNK1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WNK1 mRNA28628672
D007854LeadLead affects the splicing of WNK1 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of WNK1 mRNA"24972896
D008713MethimazoleMethimazole results in decreased expression of WNK1 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of WNK1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of WNK1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNK1 mRNA"27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of WNK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of WNK1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of WNK1 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of WNK1 mRNA24205000
D010269ParaquatParaquat results in increased expression of WNK1 mRNA21371552
D010634PhenobarbitalPhenobarbital results in decreased expression of WNK1 mRNA23091169
D011441PropylthiouracilPropylthiouracil results in decreased expression of WNK1 mRNA22504374|2478091
C513428pyrachlostrobinpyrachlostrobin results in increased expression of WNK1 mRNA27029645
C017947sodium arsenitesodium arsenite affects the expression of WNK1 mRNA19590694
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of WNK1 mRNA"26680231
C061133tamibarotenetamibarotene results in decreased expression of WNK1 mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of WNK1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WNK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WNK1 mRNA21354282
D013849ThimerosalThimerosal results in decreased expression of WNK1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of WNK1 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of WNK1 mRNA15498508
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WNK1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of WNK1 mRNA24935251|2627250
D014303TrinitrotolueneTrinitrotoluene affects the expression of WNK1 mRNA21346803
D014520UrethaneUrethane results in increased expression of WNK1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of WNK1 gene29154799
D014640VancomycinVancomycin results in increased expression of WNK1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of WNK1 gene25560391
C025643vinclozolinvinclozolin affects the expression of WNK1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of WNK1 mRNA23034163
D014750VincristineVincristine results in increased expression of WNK1 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of WNK1 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of WNK1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004672protein kinase activity-IMP16669787  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA10660600  
GO:0004674protein serine/threonine kinase activity-TAS24393035  
GO:0005515protein binding-IPI15350218  16832045  17721439  19389623  
GO:0005524ATP binding-IDA10660600  
GO:0019869chloride channel inhibitor activity-IDA17673510  
GO:0019870potassium channel inhibitor activity-IEA-  
GO:0019901protein kinase binding-IPI16669787  
GO:0019902phosphatase binding-IDA19389623  
GO:0030291protein serine/threonine kinase inhibitor activity-IEA-  
GO:0030295protein kinase activator activity-IMP16669787  
GO ID GO Term Qualifier Evidence PubMed
GO:0002028regulation of sodium ion transport-ISS-  
GO:0003084positive regulation of systemic arterial blood pressure-IEA-  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA10660600  
GO:0006468protein phosphorylation-IMP16669787  
GO:0006811ion transport-ISS-  
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO:0018107peptidyl-threonine phosphorylation-TAS24393035  
GO:0023016signal transduction by trans-phosphorylation-IDA16669787  
GO:0032147activation of protein kinase activity-IEA-  
GO:0032414positive regulation of ion transmembrane transporter activity-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IDA10660600  
GO:0035556intracellular signal transduction-TAS24393035  
GO:0046777protein autophosphorylation-IEA-  
GO:0048666neuron development-NAS15060842  
GO:0050794regulation of cellular process-ISS-  
GO:0071277cellular response to calcium ion-IEA-  
GO:0071901negative regulation of protein serine/threonine kinase activity-IEA-  
GO:0090188negative regulation of pancreatic juice secretion-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP23797875  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA10660600  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-ISS-  
GO:0016020membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24616460[Association between single nucleotide polymorphisms in Wnk1 gene and ischemic stroke in Chinese Han population]. (2014 Jan)Cai JZhejiang Da Xue Xue Bao Yi Xue Ban
15309683Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. (2004)Kokubo YJ Hum Genet