Gene: TRPC1

7220
HTRP-1|TRP1
transient receptor potential cation channel subfamily C member 1
protein-coding
3q23
Ensembl:ENSG00000144935 MIM:602343 Vega:OTTHUMG00000159301 UniprotKB:P48995
NG_030369.1
PubMed|SNP Mapped
2   ANCO-SNPs
CD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.862e-1 (AD)  4.698e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9815607chr3:142791506 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs13094259chr3:142725783 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAPPC130.922
ANKRD13C0.919
ADSS0.919
DCUN1D40.917
SLC25A360.917
PPIP5K20.916
UBR30.915
ICA1L0.915
EXOC10.914
BRWD10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.497
MTRNR2L6-0.455
MTRNR2L10-0.452
OR4F29-0.451
MTRNR2L9-0.449
EVC2-0.433
CCDC102A-0.425
CSAG1-0.421
MTRNR2L8-0.421
MTRNR2L2-0.415

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TRPC1 mRNA"27291303
D000082AcetaminophenAcetaminophen results in decreased expression of TRPC1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TRPC1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRPC1 mRNA19770486
D000584AmilorideAmiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein]19193631
D001280AtrazineAtrazine results in decreased expression of TRPC1 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of TRPC1 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of TRPC1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRPC1 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of TRPC1 mRNA26191083
D002118CalciumTRPC1 protein results in increased import of Calcium24953315
D002118CalciumLEP protein promotes the reaction [TRPC1 protein results in increased transport of Calcium]20107083
D002118CalciumTRPC1 protein results in decreased transport of Calcium22157757
D002118CalciumTRPC1 protein results in increased transport of Calcium20107083
D002118CalciumTRPC1 protein results in increased uptake of Calcium17174323
D002118CalciumTRPC1 protein results in increased transport of Calcium18822394
D002118CalciumTRPC1 protein results in increased uptake of Calcium17174323
D002118CalciumTRPC1 protein inhibits the reaction [TRPC3 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC1 protein inhibits the reaction [TRPC4 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC1 protein inhibits the reaction [TRPC5 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC1 protein inhibits the reaction [TRPC6 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC1 protein inhibits the reaction [TRPC7 protein results in increased transport of Calcium]22157757
D016572CyclosporineCyclosporine results in decreased expression of TRPC1 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of TRPC1 promoter27989131
D013759DronabinolTRPC1 results in increased susceptibility to Dronabinol16244107
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRPC1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of TRPC1 mRNA23625948
C000944dicrotophosdicrotophos results in decreased expression of TRPC1 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of TRPC1 mRNA28385952
D004317DoxorubicinTRPC1 protein affects the susceptibility to Doxorubicin16217747
D005419FlavonoidsFlavonoids results in increased expression of TRPC1 mRNA18035473
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRPC1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRPC1 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of TRPC1 mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of TRPC1 mRNA16807920
D007854LeadSTIM1 mutant form inhibits the reaction [TRPC1 protein results in increased import of Lead]24953315
D007854LeadTRPC1 protein results in increased import of Lead24953315
C008261lead acetatelead acetate results in increased expression of TRPC1 mRNA21829687
C008261lead acetatelead acetate results in increased expression of TRPC1 mRNA22674931
C008261lead acetatelead acetate results in increased expression of TRPC1 protein22674931
C100082malaoxonmalaoxon results in increased expression of TRPC1 mRNA22674931
C100082malaoxonmalaoxon results in increased expression of TRPC1 protein22674931
D008294MalathionMalathion results in increased expression of TRPC1 mRNA22674931
D008294MalathionMalathion results in increased expression of TRPC1 protein22674931
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TRPC1 mRNA19465457
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TRPC1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TRPC1 mRNA"26251327
D009151Mustard GasMustard Gas results in increased expression of TRPC1 mRNA15674844
D009532NickelNickel results in decreased expression of TRPC1 mRNA24768652|2558310
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of TRPC1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of TRPC1 mRNA19429403
D010656PhenylephrinePhenylephrine results in increased expression of TRPC1 protein17174323
D012402RotenoneRotenone results in decreased expression of TRPC1 mRNA23186747
D000068677Sildenafil CitrateSildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA]18818482
D012834SilverSilver results in decreased expression of TRPC1 mRNA27131904
D010042OuabainOuabain results in increased expression of TRPC1 protein19897708
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPC1 mRNA26377647
D013853ThioacetamideThioacetamide results in increased expression of TRPC1 mRNA23411599
D019772TopotecanTRPC1 protein affects the susceptibility to Topotecan16217747
D014635Valproic AcidValproic Acid affects the expression of TRPC1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TRPC1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of TRPC1 mRNA29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of TRPC1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005261cation channel activity-EXP18995841  
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI10097141  14505576  19052258  19897728  21408196  
GO:0015279store-operated calcium channel activity-IBA21873635  
GO:0015279store-operated calcium channel activity-TAS8663995  
GO:0070679inositol 1,4,5 trisphosphate binding-IBA21873635  
GO:0070679inositol 1,4,5 trisphosphate binding-IDA14505576  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-TAS8646775  
GO:0006828manganese ion transport-IBA21873635  
GO:0042438melanin biosynthetic process-IDA8126111  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA19052258  
GO:0051480regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0051480regulation of cytosolic calcium ion concentration-IDA19052258  
GO:0051592response to calcium ion-IDA14505576  19052258  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA14505576  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS7568191  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23840757Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. (2013)Jiang HNPLoS One
24977008Remodeling of rat pulmonary artery induced by chronic smoking exposure. (2014 Jun)Zhao LJ Thorac Dis
29068985Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease. (2017 Oct)Xu FMedicine (Baltimore)
14614461Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. (2003 Nov 20)Kim SJNature