Gene info: ID 7365

Gene: UGT2B10

GENE ID: 7365

Synonyms: UDPGT2B10

Description: UDP glucuronosyltransferase family 2 member B10

Gene type: protein-coding

Location: 4q13.2

dbXrefs: Ensembl:ENSG00000109181 MIM:600070 Vega:OTTHUMG00000161505 UniprotKB:P36537

RefSeq: NC_000004.12

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.111e-2 (AD) 7.332e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs835315	chr4:68820054 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs7657958	chr4:68817077 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR5T1	0.639
OR10X1	0.631
OR6N1	0.626
C2orf78	0.625
OR4C11	0.624
PRAMEF18	0.62
C11orf44	0.612
OR6K3	0.611
C12orf74	0.61
UGT1A6	0.61

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HGFAC	-0.229
PRKXP1	-0.22
SPAG5	-0.213
DBF4B	-0.211
SFTPC	-0.205
PNLDC1	-0.205
EMILIN3	-0.203
CPO	-0.201
LCNL1	-0.199
TBC1D3F	-0.195

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of UGT2B10 mRNA"	21346803
C060533	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"UGT2B10 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"	15986396
C060533	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"UGT2B10 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	15986396
C099565	4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol	UGT2B10 protein results in increased glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol	26452127
C099564	4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid	UGT2B10 protein results in increased chemical synthesis of 4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid	26452127
C029370	4-toluidine	4-toluidine results in increased expression of UGT2B10 mRNA	27638505
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of UGT2B10 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of UGT2B10 mRNA	21641981
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of UGT2B10 mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of UGT2B10 gene	25435355
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of UGT2B10 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of UGT2B10 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of UGT2B10 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of UGT2B10 mRNA	25181051
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of UGT2B10 mRNA	27174168
D003300	Copper	Copper deficiency results in decreased expression of UGT2B10 mRNA	19821111
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of UGT2B10 mRNA	19549813
C000944	dicrotophos	dicrotophos results in decreased expression of UGT2B10 mRNA	28302478
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of UGT2B10 mRNA	21527772
D004391	Dust	Dust results in increased expression of UGT2B10 mRNA	17805423
D020719	Glucuronides	"UGT2B10 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"	15986396
C010257	N'-nitrosoanabasine	UGT2B10 protein results in increased glucuronidation of N'-nitrosoanabasine	18238858
C032978	N'-nitrosoanatabine	UGT2B10 protein results in increased glucuronidation of N'-nitrosoanatabine	18238858
C008655	N'-nitrosonornicotine	UGT2B10 protein results in increased glucuronidation of N'-nitrosonornicotine	18238858
C464660	obeticholic acid	obeticholic acid results in increased expression of UGT2B10 mRNA	27939613
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of UGT2B10 mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of UGT2B10 mRNA	27153767
D010634	Phenobarbital	Phenobarbital affects the expression of UGT2B10 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in decreased expression of UGT2B10 mRNA	19084549
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of UGT2B10 mRNA	25895662
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of UGT2B10 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of UGT2B10 mRNA	23669205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of UGT2B10 mRNA	21724226
D014520	Urethane	Urethane results in decreased expression of UGT2B10 mRNA	28818685
C025643	vinclozolin	vinclozolin results in increased expression of UGT2B10 mRNA	22615374
D024483	Vitamin K 3	Vitamin K 3 affects the expression of UGT2B10 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008194	UDP-glycosyltransferase activity	-	IBA	21873635
GO:0015020	glucuronosyltransferase activity	NOT	IDA	8333863

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006629	lipid metabolic process	-	TAS	8333863

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	IEA	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0031090	organelle membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635

KEGG ID	KEGG Term
hsa00040	Pentose and glucuronate interconversions
hsa00053	Ascorbate and aldarate metabolism
hsa00140	Steroid hormone biosynthesis
hsa00500	Starch and sucrose metabolism
hsa00514	Other types of O-glycan biosynthesis
hsa00830	Retinol metabolism
hsa00860	Porphyrin and chlorophyll metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00983	Drug metabolism - other enzymes
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156588	Glucuronidation	TAS
R-HSA-211859	Biological oxidations	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25293881	The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. (2015 Jan)	Patel YM	Cancer Epidemiol Biomarkers Prev
18300939	Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. (2008 Mar)	Chen G	Pharmacogenet Genomics
17576790	Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (2007 Sep)	Kaivosaari S	Mol Pharmacol
29631575	The genetics of smoking in individuals with chronic obstructive pulmonary disease. (2018 Apr 10)	Obeidat M	Respir Res
23936477	Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. (2013)	Zhu AZ	PLoS One
26833182	Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. (2016 Feb 1)	Ware JJ	Sci Rep
29158210	Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways. (2018 Feb)	Taghavi T	J Pharmacol Exp Ther
24192532	The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans. (2013 Dec)	Bloom AJ	Pharmacogenet Genomics
25233931	Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups. (2014 Nov)	Murphy SE	Carcinogenesis