Gene: NDFIP1

80762
N4WBP5
Nedd4 family interacting protein 1
protein-coding
5q31.3
Ensembl:ENSG00000131507 MIM:612050 Vega:OTTHUMG00000129659 UniprotKB:Q9BT67
NC_000005.10
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.072e-1 (AD)  2.878e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1062158chr5:142143435 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7733850chr5:142135999 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7709361chr5:142134289 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6863411chr5:142133639 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11749731chr5:142120871 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4912622chr5:142111022 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs9324865chr5:142109227 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6AP20.987
REEP50.981
RAB2A0.979
PFN20.979
UBE2N0.979
CNRIP10.977
CLTC0.976
YWHAZ0.976
PCMT10.975
DNM1L0.975

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.673
OR4F29-0.627
CSAG1-0.408
RAI14-0.373
MTRNR2L6-0.372
MTRNR2L10-0.366
MTRNR2L9-0.356
MAGEA12-0.352
CXCR2-0.352
CNN2-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of NDFIP1 mRNA"25270620
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NDFIP1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NDFIP1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NDFIP1 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDFIP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDFIP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NDFIP1 mRNA17562736
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NDFIP1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NDFIP1 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NDFIP1 mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NDFIP1 protein results in decreased expression of SLC6A3 protein]26300475
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NDFIP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of NDFIP1 mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of NDFIP1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of NDFIP1 mRNA28628672
D002065BuspironeBuspirone results in increased expression of NDFIP1 mRNA24136188
D002220CarbamazepineCarbamazepine affects the expression of NDFIP1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NDFIP1 mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of NDFIP1 mRNA23811191
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NDFIP1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of NDFIP1 mRNA19167446
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NDFIP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of NDFIP1 mRNA28628672
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NDFIP1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of NDFIP1 mRNA19467301
D005839GentamicinsGentamicins results in increased expression of NDFIP1 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of NDFIP1 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NDFIP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of NDFIP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NDFIP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of NDFIP1 mRNA28628672
D008627Mercuric ChlorideMercuric Chloride affects the expression of NDFIP1 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NDFIP1 mRNA28001369
D0156551-Methyl-4-phenylpyridiniumNDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]26300475
D0156551-Methyl-4-phenylpyridiniumNDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]26300475
D0156551-Methyl-4-phenylpyridiniumNDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]26300475
D0156551-Methyl-4-phenylpyridiniumNDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]26300475
D0156551-Methyl-4-phenylpyridiniumNDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]26300475
D0156551-Methyl-4-phenylpyridiniumNDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]26300475
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NDFIP1 mRNA26924002
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NDFIP1 mRNA19074003
D010634PhenobarbitalPhenobarbital affects the expression of NDFIP1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDFIP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NDFIP1 mRNA26272509
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of NDFIP1 mRNA"21148743
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NDFIP1 mRNA19074003
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NDFIP1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NDFIP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NDFIP1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NDFIP1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDFIP1 mRNA15034205
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NDFIP1 mRNA28065790
D014212TretinoinTretinoin results in increased expression of NDFIP1 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NDFIP1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of NDFIP1 mRNA15901671
D014501UraniumUranium affects the expression of NDFIP1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of NDFIP1 mRNA15672453
D014520UrethaneUrethane results in increased expression of NDFIP1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of NDFIP1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of NDFIP1 mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18776082  19706893  25631046  
GO ID GO Term Qualifier Evidence PubMed
GO:0002761regulation of myeloid leukocyte differentiation-IEA-  
GO:0002829negative regulation of type 2 immune response-IEA-  
GO:0006879cellular iron ion homeostasis-IMP18776082  
GO:0007034vacuolar transport-IEA-  
GO:0010629negative regulation of gene expression-IMP18776082  
GO:0030001metal ion transport-IEA-  
GO:0031398positive regulation of protein ubiquitination-IDA25631046  
GO:0031398positive regulation of protein ubiquitination-IMP18776082  
GO:0032410negative regulation of transporter activity-IMP18776082  
GO:0032713negative regulation of interleukin-4 production-IEA-  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-HMP12761501  
GO:0045619regulation of lymphocyte differentiation-IEA-  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:0048294negative regulation of isotype switching to IgE isotypes-IEA-  
GO:0048302regulation of isotype switching to IgG isotypes-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0051224negative regulation of protein transport-IMP18776082  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005576extracellular region-IEA-  
GO:0005938cell cortex-IEA-  
GO:0010008endosome membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0045202synapse-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA18776082  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal