Gene: TLN2

83660
ILWEQ
talin 2
protein-coding
15q22.2
Ensembl:ENSG00000171914 MIM:607349 Vega:OTTHUMG00000133679 UniprotKB:Q9Y4G6
NG_033932.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.273e-1 (AD)  4.357e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12591037chr15:62656710 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs938979chr15:62647241 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PI4KA0.98
MYH100.976
DOCK30.976
MADD0.972
KCNMA10.971
UNC13A0.971
KALRN0.969
KCNB10.968
CNTNAP10.968
MAP3K90.965

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.55
HEY2-0.55
MYL3-0.544
COPZ2-0.543
RAI14-0.532
RAB13-0.529
RNF135-0.527
GNG11-0.52
REST-0.518
TFPI2-0.516

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TLN2 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TLN2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TLN2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TLN2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TLN2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TLN2 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLN2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TLN2 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TLN2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TLN2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TLN2 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TLN2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TLN2 mRNA21298039
C050510arsenic trichloridearsenic trichloride results in increased expression of TLN2 mRNA21750348
C050510arsenic trichloridearsenic trichloride results in increased expression of TLN2 protein21750348
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TLN2 mRNA21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of TLN2 mRNA21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TLN2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TLN2 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TLN2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TLN2 mRNA"26238291
D004958EstradiolEstradiol affects the expression of TLN2 mRNA23557687
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of TLN2 mRNA20404318
C006780bisphenol Abisphenol A affects the expression of TLN2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TLN2 mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TLN2 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of TLN2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of TLN2 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of TLN2 mRNA19174923
D016572CyclosporineCyclosporine results in decreased expression of TLN2 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of TLN2 mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TLN2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TLN2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TLN2 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of TLN2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TLN2 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of TLN2 mRNA18042831
D005485FlutamideFlutamide results in decreased expression of TLN2 mRNA21126777
D017313FenretinideFenretinide results in decreased expression of TLN2 mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of TLN2 mRNA"21635667
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TLN2 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of TLN2 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TLN2 mRNA"24972896
D008727MethotrexateMethotrexate results in increased expression of TLN2 mRNA21678067
C005219methyl cellosolvemethyl cellosolve results in increased expression of TLN2 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TLN2 protein25809596
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TLN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TLN2 mRNA"25554681
D009532NickelNickel results in decreased expression of TLN2 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of TLN2 mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of TLN2 mRNA16780908
D000073878Palm OilPalm Oil results in increased expression of TLN2 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TLN2 mRNA"25510870
D010795Phthalic AcidsPhthalic Acids results in increased expression of TLN2 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of TLN2 mRNA18301758|2081375
D012999SomanSoman results in decreased expression of TLN2 mRNA19281266
D010042OuabainOuabain results in decreased expression of TLN2 mRNA28795476
D013739TestosteroneTestosterone affects the expression of TLN2 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TLN2 mRNA16443690
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TLN2 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of TLN2 mRNA23724009
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLN2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TLN2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of TLN2 gene29154799
D014638VanadatesVanadates results in increased expression of TLN2 mRNA22714537
D014640VancomycinVancomycin results in increased expression of TLN2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TLN2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of TLN2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-NAS10320934  
GO:0005198structural molecule activity-NAS10320934  
GO:0005200structural constituent of cytoskeleton-IEA-  
GO:0005515protein binding-IPI10320934  19234221  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007016cytoskeletal anchoring at plasma membrane-IEA-  
GO:0007043cell-cell junction assembly-TAS15494027  
GO:0007155cell adhesion-NAS11907066  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-NAS10320934  
GO:0045202synapse-NAS11907066  
KEGG ID KEGG Term
hsa04510Focal adhesion
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal