Gene: TRAPPC9

83696
IBP|IKBKBBP|MRT13|NIBP|T1|TRS120
trafficking protein particle complex 9
protein-coding
8q24.3
Ensembl:ENSG00000167632 MIM:611966 Vega:OTTHUMG00000164187 UniprotKB:Q96Q05
NG_016478.2
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.262e-1 (AD)  2.293e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7014855chr8:140247165 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11773968chr8:139758768 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22637435chr8:141361108TRAPPC9Gene body4.409e-5Alcohol use disorders26763658
cg00155882chr8:141110747TRAPPC9Gene body8.091e-5Alcohol use disorders26763658
cg07878171chr8:141109731TRAPPC9Gene body8.593e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCAS30.912
ABCA30.904
RNF260.897
TMEM63B0.895
SLC45A10.891
WNK20.888
OGDHL0.887
USP50.885
AP2A10.884
TECPR10.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.519
YES1-0.504
GNG11-0.497
CLEC2B-0.489
CST7-0.476
REST-0.473
WWTR1-0.472
DISC1-0.464
TFPI2-0.464
EBF1-0.455

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TRAPPC9 mRNA"22100608
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TRAPPC9 mRNA"22100608
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of TRAPPC9 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of TRAPPC9 mRNA]28655636
D000082AcetaminophenAcetaminophen results in increased expression of TRAPPC9 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TRAPPC9 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TRAPPC9 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TRAPPC9 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TRAPPC9 mRNA19770486
D001151ArsenicArsenic affects the methylation of TRAPPC9 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRAPPC9 mRNA20106945|2210060
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRAPPC9 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRAPPC9 mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of TRAPPC9 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRAPPC9 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TRAPPC9 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TRAPPC9 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of TRAPPC9 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TRAPPC9 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRAPPC9 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TRAPPC9 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of TRAPPC9 mRNA27594783
D002945CisplatinCisplatin results in decreased phosphorylation of TRAPPC9 protein22006019
D002945CisplatinCisplatin results in decreased expression of TRAPPC9 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of TRAPPC9 mRNA28302478
D004026DieldrinDieldrin results in increased expression of TRAPPC9 mRNA23041725
D005485FlutamideFlutamide results in increased expression of TRAPPC9 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of TRAPPC9 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRAPPC9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRAPPC9 mRNA28628672
C544151jinfukangjinfukang results in increased expression of TRAPPC9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TRAPPC9 mRNA24796395
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of TRAPPC9 mRNA22100608
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRAPPC9 mRNA22100608
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRAPPC9 mRNA"20188158
D009151Mustard GasMustard Gas results in decreased expression of TRAPPC9 mRNA25102026
D009151Mustard GasMustard Gas affects the expression of TRAPPC9 mRNA15651846
C028007nickel monoxidenickel monoxide results in increased expression of TRAPPC9 mRNA19167457
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of TRAPPC9 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of TRAPPC9 mRNA28655636
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRAPPC9 mRNA22714537
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TRAPPC9 mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of TRAPPC9 mRNA29319823
D012969Sodium FluorideSodium Fluoride results in increased expression of TRAPPC9 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAPPC9 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TRAPPC9 mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of TRAPPC9 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TRAPPC9 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of TRAPPC9 gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of TRAPPC9 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TRAPPC9 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRAPPC9 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21273506  21525244  27173435  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0021987cerebral cortex development-IMP20004763  
GO:0030182neuron differentiation-IEA-  
GO:0048208COPII vesicle coating-TAS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0030008TRAPP complex-IDA21525244  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal