Gene: TIMD4

91937
SMUCKLER|TIM4
T cell immunoglobulin and mucin domain containing 4
protein-coding
5q33.3
Ensembl:ENSG00000145850 MIM:610096 Vega:OTTHUMG00000130244 UniprotKB:Q96H15
NC_000005.10
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.045e-1 (AD)  2.486e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6883317chr5:156971242 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10043150chr5:156969464 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs62382402chr5:156964807 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDO10.875
ZBP10.871
CYP19A10.866
KRTAP20-10.862
LAMP30.859
IL270.858
RUFY40.852
CCL80.849
CCL70.847
DDX60L0.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1E2-0.306
WFDC1-0.303
ATP2C2-0.293
ARSE-0.289
WNT7A-0.286
KCNIP3-0.28
NLGN3-0.274
ARSF-0.273
FOXRED2-0.269
HHATL-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TIMD4 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TIMD4 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TIMD4 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of TIMD4 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TIMD4 mRNA27339419
D019327Copper SulfateCopper Sulfate affects the expression of TIMD4 mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TIMD4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TIMD4 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of TIMD4 mRNA25016146
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TIMD4 mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TIMD4 mRNA27392435
D008353MannitolMannitol results in decreased expression of TIMD4 mRNA25270620
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TIMD4 mRNA23103053
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TIMD4 mRNA"25620056
C006253pirinixic acidpirinixic acid results in decreased expression of TIMD4 mRNA20813756
C009495titanium dioxidetitanium dioxide results in increased expression of TIMD4 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TIMD4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TIMD4 mRNA"26743178
D014635Valproic AcidValproic Acid results in decreased methylation of TIMD4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TIMD4 gene25560391
D015034Zinc OxideZinc Oxide analog results in increased expression of TIMD4 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29208769Association between the TIMD4-HAVCR1 variants and serum lipid levels, coronary heart disease and ischemic stroke risk and atorvastatin lipid-lowering efficacy. (2018 Feb 28)Zhang QHBiosci Rep