Gene: DCLK1

9201
CL1|CLICK1|DCAMKL1|DCDC3A|DCLK
doublecortin like kinase 1
protein-coding
13q13.3
Ensembl:ENSG00000133083 MIM:604742 Vega:OTTHUMG00000016729 UniprotKB:O15075
NC_000013.11
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.913e-1 (AD)  6.637e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6563354chr13:36122357 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7982504chr13:36067886 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)
rs9545925chr13:35961055 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07249860chr13:36421844DCLK1Gene body2.151e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR1580.969
ATP8A20.968
SYNJ10.966
PRKCE0.964
CADPS0.963
KIF3A0.963
NRXN30.962
CHGB0.962
TRIM370.96
MAP7D20.96

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.569
CSAG1-0.555
RAB13-0.545
CHST14-0.545
YES1-0.543
RHOD-0.541
STON2-0.539
COPZ2-0.537
HEY2-0.537
REST-0.531

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DCLK1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DCLK1 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of DCLK1 mRNA"18343893
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of DCLK1 mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DCLK1 mRNA"23994337
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of DCLK1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of DCLK1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DCLK1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DCLK1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DCLK1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DCLK1 mRNA23630614
D000393Air PollutantsAir Pollutants analog results in increased expression of DCLK1 mRNA21757418
D000447AldehydesAldehydes results in increased expression of DCLK1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DCLK1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of DCLK1 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DCLK1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of DCLK1 mRNA"25351596
D001205Ascorbic AcidAscorbic Acid results in increased expression of DCLK1 mRNA15305145
C547126AZM551248AZM551248 results in increased expression of DCLK1 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of DCLK1 mRNA23994337
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DCLK1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DCLK1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DCLK1 mRNA21839799
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of DCLK1 mRNA19619570|2010694
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of DCLK1 mRNA19693291
C044887beta-methylcholinebeta-methylcholine affects the expression of DCLK1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DCLK1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of DCLK1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of DCLK1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DCLK1 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of DCLK1 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DCLK1 mRNA17484886
C026690cerous chloridecerous chloride results in increased expression of DCLK1 mRNA23573234
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DCLK1 mRNA20938992
D003024ClozapineClozapine results in increased expression of DCLK1 mRNA18797397
D003024ClozapineClozapine results in increased expression of DCLK1 mRNA15860345
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of DCLK1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of DCLK1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of DCLK1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of DCLK1 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of DCLK1 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DCLK1 mRNA23914054
C014347decitabinedecitabine affects the expression of DCLK1 mRNA17145863
D003907DexamethasoneDexamethasone results in increased expression of DCLK1 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DCLK1 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of DCLK1 mRNA28385952
D004041Dietary FatsDietary Fats results in decreased expression of DCLK1 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DCLK1 mRNA18164116
C024629dimethyl phthalatedimethyl phthalate affects the expression of DCLK1 mRNA26924002
D004237DiuronDiuron results in decreased expression of DCLK1 mRNA25152437
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNA26159488
C118739entinostatentinostat results in decreased expression of DCLK1 mRNA27188386
C118739entinostatentinostat results in increased expression of DCLK1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLK1 mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of DCLK1 mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of DCLK1 mRNA]15016801
D005473FluoxetineFluoxetine results in increased expression of DCLK1 mRNA18301726
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DCLK1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of DCLK1 mRNA28937961
C069837fullerene C60fullerene C60 results in decreased expression of DCLK1 mRNA19167457
C039281furanfuran results in increased expression of DCLK1 mRNA27387713
D006220HaloperidolHaloperidol results in increased expression of DCLK1 mRNA18797397
D006220HaloperidolHaloperidol results in increased expression of DCLK1 mRNA15860345
D017313FenretinideFenretinide results in decreased expression of DCLK1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DCLK1 mRNA24796395|2675264
D007854LeadLead affects the expression of DCLK1 mRNA28903495
D008627Mercuric ChlorideMercuric Chloride affects the expression of DCLK1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DCLK1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of DCLK1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride affects the expression of DCLK1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DCLK1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DCLK1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of DCLK1 mRNA24810058
C500085muraglitazarmuraglitazar results in decreased expression of DCLK1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DCLK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DCLK1 mRNA"25554681
D009532NickelNickel results in decreased expression of DCLK1 mRNA24768652
C076029olanzapineolanzapine results in increased expression of DCLK1 mRNA18797397
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of DCLK1 mRNA24888373
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in increased expression of DCLK1 mRNA19176365
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of DCLK1 mRNA19176365
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DCLK1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of DCLK1 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of DCLK1 mRNA26272509
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in increased expression of DCLK1 mRNA19176365
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of DCLK1 mRNA19176365
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DCLK1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DCLK1 mRNA26705709
C046012pentanalpentanal results in increased expression of DCLK1 mRNA26079696
C006253pirinixic acidpirinixic acid results in increased expression of DCLK1 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of DCLK1 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of DCLK1 mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DCLK1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of DCLK1 mRNA19693291
C005556propionaldehydepropionaldehyde results in increased expression of DCLK1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of DCLK1 mRNA24780913
C502851quinocetonequinocetone results in increased expression of DCLK1 mRNA27046791
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of DCLK1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of DCLK1 protein25505154
C089730rosiglitazonerosiglitazone results in decreased expression of DCLK1 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DCLK1 mRNA25895662
D012999SomanSoman results in increased expression of DCLK1 mRNA19281266
C501413tesaglitazartesaglitazar results in decreased expression of DCLK1 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of DCLK1 mRNA19693291
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNA26159488
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCLK1 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCLK1 mRNA18343893|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLK1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DCLK1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCLK1 mRNA15328365|2399433
C009495titanium dioxidetitanium dioxide results in increased expression of DCLK1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of DCLK1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DCLK1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of DCLK1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of DCLK1 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of DCLK1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of DCLK1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of DCLK1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of DCLK1 mRNA21515302
D014520UrethaneUrethane results in decreased expression of DCLK1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCLK1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DCLK1 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of DCLK1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of DCLK1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DCLK1 gene25487561
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DCLK1 gene25560391
C111237vorinostatvorinostat results in decreased expression of DCLK1 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DCLK1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS9747029  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0006468protein phosphorylation-TAS9747029  
GO:0007399nervous system development-TAS10036192  
GO:0007417central nervous system development-TAS10051403  
GO:0009615response to virus-IEP16548883  
GO:0016197endosomal transport-NAS14613930  
GO:0021952central nervous system projection neuron axonogenesis-IEA-  
GO:0030900forebrain development-IEA-  
GO:0048675axon extension-IEA-  
GO:0048812neuron projection morphogenesis-IBA21873635  
GO:0048813dendrite morphogenesis-IEA-  
GO:1900181negative regulation of protein localization to nucleus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS10036192  
GO:0014069postsynaptic density-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal