Gene: DLGAP2

9228
C8orf68|DAP2|ERICH1-AS1|SAPAP2
DLG associated protein 2
protein-coding
8p23.3
Ensembl:ENSG00000198010 MIM:605438 Vega:OTTHUMG00000163599 UniprotKB:Q9P1A6
NG_009409.2
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.745e-1 (AD)  9.468e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7005715chr8:1701794 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7825359chr8:1699869 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17064176chr8:1652979 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00579531chr8:1495332DLGAP2Promoter1.034e-4Alcohol use disorders26763658
cg27316067chr8:1592451DLGAP2Gene body3.540e-4Alcohol use disorders26763658
cg03185622chr8:1501226DLGAP25.250e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UNC790.963
CSMD10.962
KCNMA10.96
KCNB10.954
R3HDM10.952
KALRN0.951
CACNA1B0.951
KIAA1549L0.95
TANC20.95
DRP20.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.587
RAB13-0.575
SNHG18-0.573
MYL3-0.564
COPZ2-0.564
YES1-0.551
ROM1-0.544
ZNF114-0.537
RAI14-0.536
CSAG1-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of DLGAP2 mRNA26690555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DLGAP2 mRNA16483693
D001151ArsenicArsenic affects the methylation of DLGAP2 gene25304211
D001280AtrazineAtrazine results in decreased expression of DLGAP2 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of DLGAP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DLGAP2 gene28505145
D004390ChlorpyrifosChlorpyrifos results in decreased expression of DLGAP2 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of DLGAP220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DLGAP2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DLGAP2 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of DLGAP2 mRNA26577399|2752363
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DLGAP2 mRNA28962523
D008559MemantineMemantine inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]24333387
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLGAP2 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of DLGAP220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DLGAP2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DLGAP2 mRNA20938992
D007052IbuprofenIbuprofen inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]24333387
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of DLGAP220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DLGAP2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DLGAP2 mRNA20938992
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of DLGAP2 mRNA19074003
D011441PropylthiouracilPropylthiouracil results in decreased expression of DLGAP2 mRNA24780913
C089730rosiglitazonerosiglitazone affects the expression of DLGAP2 mRNA21515302
C017947sodium arsenitesodium arsenite affects the methylation of DLGAP2 gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of DLGAP2 mRNA18175754
D013311StreptozocinIbuprofen inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]24333387
D013311StreptozocinMemantine inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]24333387
D013311StreptozocinStreptozocin results in decreased expression of DLGAP2 mRNA24333387
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of DLGAP2 mRNA19074003
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLGAP2 mRNA17942748
C012589trichostatin Atrichostatin A results in decreased expression of DLGAP2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of DLGAP2 mRNA21515302
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DLGAP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007270neuron-neuron synaptic transmission-NAS9694864  
GO ID GO Term Qualifier Evidence PubMed
GO:0005883neurofilament-NAS10759891  
GO:0005886plasma membrane-TAS-  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal