Gene: ADAMTSL1

92949
ADAMTSL-1|ADAMTSR1|C9orf94|PUNCTIN
ADAMTS like 1
protein-coding
9p22.2-p22.1
Ensembl:ENSG00000178031 MIM:609198 Vega:OTTHUMG00000019604 UniprotKB:Q8N6G6
NC_000009.12
PubMed|SNP Mapped
8   ANCO-SNPs
ND|AD
1   
4.799e-1 (AD)  7.476e-2 (ND)   (Frontal_Cortex)
6.430e-1 (AD)  7.838e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10963662chr9:18601141 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10120545chr9:18386759 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10810935chr9:18251857 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17198023chr9:18194385 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs34236855chr9:18178316 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12006002chr9:18166901 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs763976chr9:18134916 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10963462chr9:18130038 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A80.776
SCN8A0.765
PCDHGC50.761
DCLK10.759
LHFPL40.754
PCSK10.754
GPR1790.754
HECW10.754
BMPER0.754
PLBD20.753

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.538
RAB13-0.522
YES1-0.507
COPZ2-0.503
MYL3-0.488
ROM1-0.488
IMPA2-0.485
NUPR1-0.48
CHST14-0.478
HEY2-0.475

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ADAMTSL1 mRNA"28903501
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ADAMTSL1 mRNA24449571
D001151ArsenicArsenic affects the methylation of ADAMTSL1 gene25304211
C015001arsenitearsenite results in increased methylation of ADAMTSL1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAMTSL1 mRNA22316170
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ADAMTSL1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ADAMTSL1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ADAMTSL1 mRNA28628672
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADAMTSL1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of ADAMTSL1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ADAMTSL1 mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ADAMTSL1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ADAMTSL1 mRNA28628672
C118739entinostatentinostat results in increased expression of ADAMTSL1 mRNA27188386
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ADAMTSL1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ADAMTSL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ADAMTSL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ADAMTSL1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADAMTSL1 mRNA24796395
C008261lead acetatelead acetate results in increased expression of ADAMTSL1 mRNA20542052|2261322
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADAMTSL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADAMTSL1 mRNA"25554681
D009532NickelNickel results in increased expression of ADAMTSL1 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of ADAMTSL1 mRNA22714537
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ADAMTSL1 mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of ADAMTSL1 mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of ADAMTSL1 mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAMTSL1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of ADAMTSL1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of ADAMTSL1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADAMTSL1 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of ADAMTSL1 mRNA21795629
D014635Valproic AcidValproic Acid results in increased expression of ADAMTSL1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of ADAMTSL1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ADAMTSL1 mRNA17963808
D014638VanadatesVanadates results in increased expression of ADAMTSL1 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008233peptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28440896Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. (2017 Apr 25)Yin XAm J Med Genet B Neuropsychiatr Genet