Gene: NRXN3

9369
C14orf60
neurexin 3
protein-coding
14q24.3-q31.1
Ensembl:ENSG00000021645 MIM:600567 Vega:OTTHUMG00000171502 UniprotKB:Q9HDB5
NG_052991.1
PubMed|SNP Mapped
5   ANCO-SNPs
CD|OD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.543e-1 (AD)  6.191e-4 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2293843chr14:79854405 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17754467chr14:78156180 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4903712chr14:78149250 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10483889chr14:78091162 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4903705chr14:78089598 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR1580.971
MYT1L0.967
PAK30.966
PGM2L10.966
RAB3C0.965
NBEA0.965
ATP8A20.965
SCAI0.964
CNTNAP20.964
FRMPD40.964

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.607
RNF135-0.596
RAB13-0.591
ROM1-0.57
HEY2-0.568
CHST14-0.567
YES1-0.564
REST-0.561
MYL3-0.556
RAI14-0.554

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NRXN3 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NRXN3 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NRXN3 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NRXN3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NRXN3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NRXN3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NRXN3 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NRXN3 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of NRXN3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NRXN3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NRXN3 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of NRXN3 mRNA26705709
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NRXN3 mRNA22316170
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of NRXN3 mRNA20660070
D004958EstradiolEstradiol results in increased expression of NRXN3 mRNA22411564
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of NRXN3 mRNA]22411564
C006780bisphenol Abisphenol A results in decreased expression of NRXN3 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of NRXN3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NRXN3 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of NRXN3 mRNA25979313
C026690cerous chloridecerous chloride results in increased expression of NRXN3 mRNA23573234
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of NRXN3 mRNA26272509
D000069439DasatinibDasatinib results in increased expression of NRXN3 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NRXN3 mRNA23914054
D013759DronabinolDronabinol results in decreased expression of NRXN3 mRNA21955143
D013759DronabinolDronabinol results in decreased expression of NRXN3 mRNA16616335
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NRXN3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NRXN3 mRNA27392435
D000431EthanolEthanol results in decreased expression of NRXN3 mRNA21955143
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NRXN3 mRNA29097150
C540355fenamidonefenamidone results in decreased expression of NRXN3 mRNA27029645
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NRXN3 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NRXN3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NRXN3 mRNA26752646
D007854LeadLead affects the expression of NRXN3 mRNA28903495
D007854LeadLead affects the splicing of NRXN3 mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NRXN3 mRNA26378955
C042720mercuric bromidemercuric bromide results in decreased expression of NRXN3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NRXN3 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NRXN3 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of NRXN3 mRNA17412507
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NRXN3 mRNA26558463
D009020MorphineMorphine results in increased expression of NRXN3 mRNA21955143
D009532NickelNickel results in decreased expression of NRXN3 mRNA25583101
D009538NicotineNicotine results in increased expression of NRXN3 mRNA21955143
D010269ParaquatParaquat results in increased expression of NRXN3 mRNA18198484
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NRXN3 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of NRXN3 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of NRXN3 mRNA16293270
D011189Potassium ChloridePotassium Chloride results in increased expression of NRXN3 mRNA16412482
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NRXN3 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of NRXN3 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of NRXN3 mRNA21540246
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of NRXN3 mRNA]22411564
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NRXN3 mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of NRXN3 gene28589171
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NRXN3 mRNA26378955
D013806TheophyllineTheophylline results in increased expression of NRXN3 mRNA16083514
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NRXN3 mRNA19969065
D014050TolueneToluene results in increased expression of NRXN3 mRNA22967744
D014212TretinoinTretinoin results in increased expression of NRXN3 mRNA21934132|2383079
C012589trichostatin Atrichostatin A results in decreased expression of NRXN3 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of NRXN3 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of NRXN3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NRXN3 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of NRXN3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NRXN3 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NRXN3 gene25560391
C025643vinclozolinvinclozolin affects the expression of NRXN3 mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRXN3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of NRXN3 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0038023signaling receptor activity-TAS1621094  
GO:0046872metal ion binding-IEA-  
GO:0050839cell adhesion molecule binding-TAS18923512  
GO:0097109neuroligin family protein binding-TAS18923512  
GO ID GO Term Qualifier Evidence PubMed
GO:0007158neuron cell-cell adhesion-TAS18923512  
GO:0007165signal transduction-IEA-  
GO:0007411axon guidance-TAS1621094  
GO:0007612learning-IGI22209245  
GO:0030534adult behavior-IGI22209245  
GO:0035176social behavior-IGI22209245  
GO:0071625vocalization behavior-IGI22209245  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1621094  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17804423Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. (2007 Dec 1)Hishimoto AHum Mol Genet
21676558Associations among types of impulsivity, substance use problems and neurexin-3 polymorphisms. (2011 Dec 15)Stoltenberg SFDrug Alcohol Depend
22716474Association of neurexin 3 polymorphisms with smoking behavior. (2012 Aug)Docampo EGenes Brain Behav
19658047Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study. (2009)Novak GWorld J Biol Psychiatry
17409192Genomewide suggestive linkage of opioid dependence to chromosome 14q. (2007 Jun 1)Lachman HMHum Mol Genet
25189868Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (2015 Mar)Sung YJAm J Hypertens
18418251Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction. (2008 May 7)Kelai SNeuroreport
23909413Gene x smoking interactions on human brain gene expression: finding common mechanisms in adolescents and adults. (2013 Oct)Wolock SLJ Child Psychol Psychiatry
26597164RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. (2015 Nov 23)Webb ABMC Genomics