Gene: KIAA0040

9674
-
KIAA0040
protein-coding
1q25.1
Ensembl:ENSG00000235750 MIM:616696 Vega:OTTHUMG00000034880 UniprotKB:Q15053
NC_000001.11
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.715e-6 (AD)  4.997e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10489326chr1:175165541 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1894709chr1:175163235 (GRCh38.p7)G>Talcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)
rs1057239chr1:175161068 (GRCh38.p7)G>Aalcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)
rs4650716chr1:175159575 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1057302chr1:175157287 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF10.864
WWTR10.864
IFI160.857
YBX30.841
PLSCR10.84
CD930.838
CASP40.834
S1PR30.832
ANXA20.829
TAGLN20.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.614
LRTM2-0.598
EXTL1-0.596
CHRM1-0.585
KCNQ4-0.579
MYADML2-0.575
KCNA2-0.573
TMEM179-0.573
KCNK4-0.569
RTN4R-0.569

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of KIAA0040 mRNA29067470
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of KIAA0040 mRNA"23195993
C068073Am 580Am 580 results in decreased expression of KIAA0040 mRNA16982809
C487081belinostatbelinostat results in increased expression of KIAA0040 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C018475butyraldehydebutyraldehyde results in increased expression of KIAA0040 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KIAA0040 mRNA26472689
D016572CyclosporineCyclosporine results in decreased expression of KIAA0040 mRNA20106945
D002945CisplatinCisplatin results in increased expression of KIAA0040 mRNA27392435
C118739entinostatentinostat results in increased expression of KIAA0040 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
D005472FluorouracilFluorouracil results in increased expression of KIAA0040 mRNA16510598
D017313FenretinideFenretinide results in decreased expression of KIAA0040 mRNA28973697
C051890irinotecanirinotecan analog results in increased expression of KIAA0040 mRNA18927307
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KIAA0040 mRNA27432991
D009532NickelNickel results in decreased expression of KIAA0040 mRNA23195993
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of KIAA0040 mRNA26272509
C089730rosiglitazonerosiglitazone results in decreased expression of KIAA0040 mRNA16982809
D012643SeleniumSelenium results in increased expression of KIAA0040 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of KIAA0040 mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIAA0040 mRNA20106945
C012589trichostatin Atrichostatin A results in increased expression of KIAA0040 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of KIAA0040 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA0040 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of KIAA0040 mRNA24383497|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25359488Genetics of alcohol dependence: a review of clinical studies. (2014)Samochowiec JNeuropsychobiology
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. (2011 Nov)Wang KSJ Psychiatr Res
24829844Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families. (2013 Dec)Hill SYOpen J Genet
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (2012 Jan)Zuo LNeuropsychopharmacology
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict