Gene: MELK

9833
HPK38
maternal embryonic leucine zipper kinase
protein-coding
9p13.2
Ensembl:ENSG00000165304 MIM:607025 Vega:OTTHUMG00000019906 UniprotKB:Q14680
NC_000009.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.520e-2 (AD)  8.548e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2246564chr9:36638248 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10972978chr9:36576850 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2C0.637
HJURP0.59
CEP550.578
TREML40.577
MKI670.576
KIF20A0.575
TOP2A0.569
ASF1B0.565
CD1630.56
PBK0.547

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHOSPHO1-0.272
ZNF575-0.271
OTOA-0.27
ATP2C2-0.269
ASPDH-0.266
SPEF1-0.264
CALML3-0.263
KIT-0.263
SLC7A4-0.26
HES6-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MELK mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MELK mRNA"23829299
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MELK mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MELK mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MELK mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MELK mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MELK mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MELK mRNA"23829299
D000082AcetaminophenAcetaminophen results in increased expression of MELK mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MELK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MELK mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MELK mRNA23630614
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MELK mRNA"22863853
C015001arsenitearsenite results in decreased expression of MELK mRNA18929588
D001379AzathioprineAzathioprine results in decreased expression of MELK mRNA22623647
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MELK mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MELK mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MELK mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MELK mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MELK mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of MELK mRNA16474171|1916744
D004958EstradiolEstradiol results in increased expression of MELK mRNA19484750
C522781biflorinbiflorin affects the expression of MELK mRNA27079618
C006780bisphenol Abisphenol A affects the expression of MELK mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MELK mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MELK mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of MELK mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of MELK promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MELK mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MELK mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MELK mRNA20938992
D003033Coal TarCoal Tar results in increased expression of MELK mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of MELK mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of MELK mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of MELK mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MELK mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MELK mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of MELK mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of MELK mRNA22077320
D003471CuprizoneCuprizone results in increased expression of MELK mRNA26577399
D003520CyclophosphamideMELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D016572CyclosporineCyclosporine results in decreased expression of MELK mRNA20106945|2556210
D000069439DasatinibDasatinib results in decreased expression of MELK mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MELK mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MELK mRNA19561079
D002945CisplatinCisplatin results in increased expression of MELK mRNA27594783
D002945CisplatinCisplatin results in decreased expression of MELK mRNA22023808
C000944dicrotophosdicrotophos results in decreased expression of MELK mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of MELK mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MELK mRNA21592394
D004147DioxinsDioxins affects the expression of MELK mRNA20463971
D004317DoxorubicinMELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MELK mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MELK mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MELK mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MELK mRNA17351261
D005472FluorouracilMELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D005472FluorouracilMELK protein affects the susceptibility to Fluorouracil15548681
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of MELK mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MELK mRNA20938992
C039281furanfuran results in increased expression of MELK mRNA25539665
C039281furanfuran results in increased methylation of MELK gene22079235
D019833GenisteinGenistein results in increased expression of MELK mRNA16474171
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MELK mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MELK mRNA24796395
D008154LucanthoneLucanthone results in decreased expression of MELK mRNA21148553
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MELK mRNA20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of MELK mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of MELK mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of MELK mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MELK mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of MELK mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MELK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MELK mRNA"25554681
D009532NickelNickel results in increased expression of MELK mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MELK mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of MELK mRNA26516004
D010126OzoneOzone results in decreased expression of MELK mRNA24336422
D017239PaclitaxelMELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C500026palbociclibpalbociclib results in decreased expression of MELK mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MELK mRNA"25510870
C410127PCB 180PCB 180 results in increased expression of MELK mRNA23829299
D010634PhenobarbitalPhenobarbital results in increased expression of MELK mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of MELK mRNA21061450
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of MELK mRNA16474171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MELK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MELK mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of MELK mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of MELK mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of MELK mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MELK mRNA19167446
C059514resveratrolresveratrol results in increased expression of MELK mRNA19167446
C017947sodium arsenitesodium arsenite inhibits the reaction [E2F1 protein binds to MELK promoter]17998272
C017947sodium arsenitesodium arsenite promotes the reaction [E2F4 protein binds to MELK promoter]17998272
C017947sodium arsenitesodium arsenite results in decreased expression of MELK mRNA17998272
D053260SootSoot results in increased expression of MELK mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 results in decreased expression of MELK mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of MELK mRNA27225895
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MELK mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MELK mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MELK mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MELK mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MELK mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MELK mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MELK mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MELK mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of MELK mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of MELK mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of MELK mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MELK mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MELK mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MELK mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MELK mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MELK mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MELK mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MELK mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of MELK mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MELK mRNA29154799
D014747VinblastineMELK protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in increased expression of MELK mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of MELK mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA12400006  15908796  16216881  17280616  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IDA16216881  
GO:0005509calcium ion binding-IDA16216881  
GO:0005515protein binding-IPI12400006  15908796  17280616  
GO:0005524ATP binding-IEA-  
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS12400006  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006915apoptotic process-IDA17280616  
GO:0008283cell proliferation-IDA17280616  
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030097hemopoiesis-ISS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0046777protein autophosphorylation-IDA16216881  
GO:0061351neural precursor cell proliferation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IDA21145462  
GO:0005938cell cortex-IDA16159311  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal