DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SPOP_SBC_1

Location: 1549:1553

E3 ligase: SPOP

DEGRON score: 0.9738

ASA_SCORE: 81.42

COIL: 0.824

CONS_SCORE: 0.4897

DSS_SCORE: 0.549

HELIX: 0.1548

FCONS_SCORE: 1.0943

RIG_SCORE: 0.7469

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1546T	TCGA-AX-A1CF	UCEC	TCGA	AWTTS	DEG_SPOP_SBC_1	0.25
p.A1546T	DO43795	UCEC	ICGC	AWTTS	DEG_SPOP_SBC_1	0.25
p.A1541V	TCGA-D5-6928	COAD	TCGA	AWTTS	DEG_SPOP_SBC_1	0.1111
p.A1541V	DO7776	COAD	ICGC	AWTTS	DEG_SPOP_SBC_1	0.1111
p.E1540D	TCGA-FI-A2D6	UCEC	TCGA	AWTTS	DEG_SPOP_SBC_1	0.0833
p.E1540D	DO43867	UCEC	ICGC	AWTTS	DEG_SPOP_SBC_1	0.0833
p.V1542L	DO229041	LICA	ICGC	AWTTS	DEG_SPOP_SBC_1	0.1389
p.P1562T	ACH-000844	Lung Cancer	CCLE	AWTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1549:1553	AWTTS	SPOP	0.9738	More...
Q0VD83	Apolipoprotein B receptor	DEG_SPOP_SBC_1	372:376	AWTTS	SPOP	0.9922	More...
A8MTL3	RING finger protein 212B	DEG_SPOP_SBC_1	295:299	AWTTS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons