DegronMD

Uniprot ID: Q0VD83

Source protein: Apolipoprotein B receptor

Source gene: APOBR

Class: DEG_SPOP_SBC_1

Location: 372:376

E3 ligase: SPOP

DEGRON score: 0.9922

ASA_SCORE: 83.96

COIL: 0.7664

CONS_SCORE: 0.7248

DSS_SCORE: 0.6316

HELIX: 0.1958

FCONS_SCORE: 1.2067

RIG_SCORE: 0.7221

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G369E	TCGA-E1-5302	LGG	TCGA	AWTTS	DEG_SPOP_SBC_1	0.25
p.A366T	TCGA-YA-A8S7	LIHC	TCGA	AWTTS	DEG_SPOP_SBC_1	0.1667
p.W364G	DO222905	BTCA	ICGC	AWTTS	DEG_SPOP_SBC_1	0.1111
p.A372V	DO233179	GACA	ICGC	AWTTS	DEG_SPOP_SBC_1	0.5825
p.G383R	DO222632	MELA	ICGC	AWTTS	DEG_SPOP_SBC_1	0.1389
p.G383R	DO37571	SKCM	ICGC	AWTTS	DEG_SPOP_SBC_1	0.1389
p.P386Q	DO37511	SKCM	ICGC	AWTTS	DEG_SPOP_SBC_1	0.0556
p.P386Q	DO37571	SKCM	ICGC	AWTTS	DEG_SPOP_SBC_1	0.0556
p.P386Q	DO47459	SKCM	ICGC	AWTTS	DEG_SPOP_SBC_1	0.0556
p.P386S	DO47331	SKCM	ICGC	AWTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1549:1553	AWTTS	SPOP	0.9738	More...
Q0VD83	Apolipoprotein B receptor	DEG_SPOP_SBC_1	372:376	AWTTS	SPOP	0.9922	More...
A8MTL3	RING finger protein 212B	DEG_SPOP_SBC_1	295:299	AWTTS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons