DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
AWTTS
Uniprot ID:
A8MTL3
Source protein:
RING finger protein 212B
Source gene:
RNF212B
Class:
DEG_SPOP_SBC_1
Location:
295:299
E3 ligase:
SPOP
DEGRON score:
0.8048
ASA_SCORE:
92.2
COIL:
0.8206
CONS_SCORE:
0.3243
DSS_SCORE:
0.8384
HELIX:
0.1438
FCONS_SCORE:
0.987
RIG_SCORE:
0.7381
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.W296R
SNU-C5
large_intestine
COSMIC
AWTTS
DEG_SPOP_SBC_1
0.7523
p.W296R
BHY
upper_aerodigestive_tract
COSMIC
AWTTS
DEG_SPOP_SBC_1
0.7523
Drug responses associated with RNF212B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AWTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1L4H1
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
DEG_SPOP_SBC_1
1549:1553
AWTTS
SPOP
0.9738
More...
Q0VD83
Apolipoprotein B receptor
DEG_SPOP_SBC_1
372:376
AWTTS
SPOP
0.9922
More...
A8MTL3
RING finger protein 212B
DEG_SPOP_SBC_1
295:299
AWTTS
SPOP
0.8048
More...