DegronMD

Uniprot ID: A6NIR3

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Source gene: AGAP5

Class: DEG_SCF_FBW7_1

Location: 218:225

E3 ligase: FBXW7

DEGRON score: 0.9909

ASA_SCORE: 73.55

COIL: 0.9504

CONS_SCORE: 0.3366

DSS_SCORE: 0.6366

HELIX: 0.0235

FCONS_SCORE: 1.0152

RIG_SCORE: 0.5609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S215P	TCGA-B5-A3FA	UCEC	TCGA	IPSTPSTS	DEG_SCF_FBW7_1	0.25
p.S215P	DO52402	UCEC	ICGC	IPSTPSTS	DEG_SCF_FBW7_1	0.25
p.G208C	ACH-000960	Leukemia	CCLE	IPSTPSTS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SCF_FBW7_1	218:225	IPSTPSTS	FBXW7	0.9909	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SCF_FBW7_1	195:202	IPSTPSTS	FBXW7	0.9922	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SCF_FBW7_1	195:202	IPSTPSTS	FBXW7	0.9894	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SCF_FBW7_1	195:202	IPSTPSTS	FBXW7	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons