DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IPSTPSTS
Uniprot ID:
Q5VUJ5
Source protein:
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
Source gene:
AGAP7P
Class:
DEG_SCF_FBW7_1
Location:
195:202
E3 ligase:
FBXW7
DEGRON score:
0.9922
ASA_SCORE:
70.05
COIL:
0.9469
CONS_SCORE:
0.248
DSS_SCORE:
0.6366
HELIX:
0.0196
FCONS_SCORE:
0.9033
RIG_SCORE:
0.5609
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AGAP7P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IPSTPSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NIR3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
DEG_SCF_FBW7_1
218:225
IPSTPSTS
FBXW7
0.9909
More...
Q5VUJ5
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
DEG_SCF_FBW7_1
195:202
IPSTPSTS
FBXW7
0.9922
More...
Q5VW22
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
DEG_SCF_FBW7_1
195:202
IPSTPSTS
FBXW7
0.9894
More...
Q96P64
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
DEG_SCF_FBW7_1
195:202
IPSTPSTS
FBXW7
0.9973
More...