DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IPSTPSTS
Uniprot ID:
Q96P64
Source protein:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
Source gene:
AGAP4
Class:
DEG_SCF_FBW7_1
Location:
195:202
E3 ligase:
FBXW7
DEGRON score:
0.9973
ASA_SCORE:
72.975
COIL:
0.9423
CONS_SCORE:
0.3295
DSS_SCORE:
0.6311
HELIX:
0.0208
FCONS_SCORE:
1.6098
RIG_SCORE:
0.5611
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AGAP4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IPSTPSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NIR3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
DEG_SCF_FBW7_1
218:225
IPSTPSTS
FBXW7
0.9909
More...
Q5VUJ5
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
DEG_SCF_FBW7_1
195:202
IPSTPSTS
FBXW7
0.9922
More...
Q5VW22
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
DEG_SCF_FBW7_1
195:202
IPSTPSTS
FBXW7
0.9894
More...
Q96P64
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
DEG_SCF_FBW7_1
195:202
IPSTPSTS
FBXW7
0.9973
More...