DegronMD

Uniprot ID: Q5VW22

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Source gene: AGAP6

Class: DEG_SCF_FBW7_1

Location: 195:202

E3 ligase: FBXW7

DEGRON score: 0.9894

ASA_SCORE: 73.9625

COIL: 0.9526

CONS_SCORE: 0.3482

DSS_SCORE: 0.6311

HELIX: 0.0185

FCONS_SCORE: 0.9986

RIG_SCORE: 0.5611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H200R	TCGA-DK-A3IU	BLCA	TCGA	IPSTPSTS	DEG_SCF_FBW7_1	0.8244
p.S197L	DO228950	LICA	ICGC	IPSTPSTS	DEG_SCF_FBW7_1	0.6556
p.P196L	DO222753	MELA	ICGC	IPSTPSTS	DEG_SCF_FBW7_1	0.6471
p.A195V	SIDM00602	Gastric Carcinoma	GDSC	IPSTPSTS	DEG_SCF_FBW7_1	0.6936
p.A195V	IM-95	stomach	COSMIC	IPSTPSTS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SCF_FBW7_1	218:225	IPSTPSTS	FBXW7	0.9909	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SCF_FBW7_1	195:202	IPSTPSTS	FBXW7	0.9922	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SCF_FBW7_1	195:202	IPSTPSTS	FBXW7	0.9894	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SCF_FBW7_1	195:202	IPSTPSTS	FBXW7	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons