DegronMD

Uniprot ID: Q8WU08

Source protein: Serine/threonine-protein kinase 32A

Source gene: STK32A

Class: LIG_APCC_ABBAyCdc20_2

Location: 8:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5629

ASA_SCORE: 106.5714

COIL: 0.9599

CONS_SCORE: 0.6018

DSS_SCORE: 0.5257

HELIX: 0.0173

FCONS_SCORE: 0.9415

RIG_SCORE: 0.734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V18A	TCGA-AA-3663	COAD	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V18A	DO9346	COAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H22Y	TCGA-AP-A1DK	UCEC	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H22Y	DO42033	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P9R	TCGA-CG-5733	STAD	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.6401
p.P9R	DO38551	STAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.6401
p.A3V	TCGA-E2-A574	BRCA	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A3V	DO49022	BRCA	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P10Q	TCGA-GN-A26C	SKCM	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.5924
p.P10Q	DO37782	SKCM	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.5924
p.F12V	DO234413	ESAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.7068
p.R7K	SIDM01617	Endometrial Carcinoma	GDSC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R7K	ACH-000994	Endometrial/Uterine Cancer	CCLE	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU08	Serine/threonine-protein kinase 32A	LIG_APCC_ABBAyCdc20_2	8:14	KPPVFDE	APC,CDC20,FZR1	0.5629	More...
Q9NY57	Serine/threonine-protein kinase 32B	LIG_APCC_ABBAyCdc20_2	8:14	KPPVFDE	APC,CDC20,FZR1	0.7199	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons