DegronMD

Uniprot ID: Q9NY57

Source protein: Serine/threonine-protein kinase 32B

Source gene: STK32B

Class: LIG_APCC_ABBAyCdc20_2

Location: 8:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7199

ASA_SCORE: 106.7143

COIL: 0.9619

CONS_SCORE: 0.383

DSS_SCORE: 0.5763

HELIX: 0.0136

FCONS_SCORE: 0.722

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V11M	TCGA-DF-A2KU	UCEC	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.6097
p.V11M	DO223286	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.6097
p.G3W	TCGA-MN-A4N5	LUAD	TCGA	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G3W	DO45332	LUAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A3V	DO230346	COCA	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E24K	DO234344	ESAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R23W	DO16077	HNSC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R23W	DO47933	STAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.F22L	DO22205	LGG	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E17D	DO229037	LICA	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.A3S	DO229041	LICA	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.M7T	DO50973	LICA	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.V21D	DO44915	LIHC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P10R	DO23342	LINC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.6401
p.R23L	DO23586	LUAD	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R19Q	DO43306	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R19Q	DO41379	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E14K	DO41572	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.7022
p.R15M	DO41572	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q10H	DO41903	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.7582
p.R19W	DO43907	UCEC	ICGC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.F20I	SIDM00941	Kidney Carcinoma	GDSC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F20I	ACH-000433	Kidney Cancer	CCLE	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F20I	CAKI-1	kidney	COSMIC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G3R	SIDM00901	Endometrial Carcinoma	GDSC	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G3R	ACH-000940	Endometrial/Uterine Cancer	CCLE	KPPVFDE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU08	Serine/threonine-protein kinase 32A	LIG_APCC_ABBAyCdc20_2	8:14	KPPVFDE	APC,CDC20,FZR1	0.5629	More...
Q9NY57	Serine/threonine-protein kinase 32B	LIG_APCC_ABBAyCdc20_2	8:14	KPPVFDE	APC,CDC20,FZR1	0.7199	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPPVFDE

Degron related mutations and impact score

Drug responses associated with STK32B mutations

All proteins holding degron of KPPVFDE