DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LSLFDE
Uniprot ID:
Q641Q2
Source protein:
WASH complex subunit 2A
Source gene:
WASHC2A
Class:
LIG_APCC_ABBA_1
Location:
801:806
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9968
ASA_SCORE:
78.9667
COIL:
0.6432
CONS_SCORE:
0.4889
DSS_SCORE:
0.5649
HELIX:
0.2745
FCONS_SCORE:
1.455
RIG_SCORE:
0.7962
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with WASHC2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSLFDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q641Q2
WASH complex subunit 2A
LIG_APCC_ABBA_1
801:806
LSLFDE
APC,CDC20,FZR1
0.9968
More...
Q9Y4E1
WASH complex subunit 2C
LIG_APCC_ABBA_1
801:806
LSLFDE
APC,CDC20,FZR1
0.9951
More...