DegronMD

Uniprot ID: A1L443

Source protein: NUT family member 2F

Source gene: NUTM2F

Class: DEG_SIAH_1

Location: 161:169

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8871

ASA_SCORE: 70.6889

COIL: 0.8118

CONS_SCORE: 0.3706

DSS_SCORE: 0.6044

HELIX: 0.0851

FCONS_SCORE: 0.9098

RIG_SCORE: 0.6719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P179T	TCGA-17-Z031	LUAD	TCGA	PPAAQVAPI	DEG_SIAH_1	0.0556
p.V170M	TCGA-CA-6717	COAD	TCGA	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	DO8264	COAD	ICGC	PPAAQVAPI	DEG_SIAH_1	0.3056
p.A175G	TCGA-IE-A6BZ	SARC	TCGA	PPAAQVAPI	DEG_SIAH_1	0.1667
p.A175G	DO220159	SARC	ICGC	PPAAQVAPI	DEG_SIAH_1	0.1667
p.R176G	DO219873	SKCA	ICGC	PPAAQVAPI	DEG_SIAH_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons