DegronMD

Uniprot ID: Q5VZR2

Source protein: NUT family member 2G

Source gene: NUTM2G

Class: DEG_SIAH_1

Location: 161:169

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9092

ASA_SCORE: 68.7111

COIL: 0.829

CONS_SCORE: 0.4537

DSS_SCORE: 0.6028

HELIX: 0.1036

FCONS_SCORE: 0.909

RIG_SCORE: 0.6735

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V170M	TCGA-2W-A8YY	CESC	TCGA	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	TCGA-FR-A726	SKCM	TCGA	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	DO223732	CESC	ICGC	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	DO48665	SKCM	ICGC	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	SIDM00621	Ewing's Sarcoma	GDSC	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	ACH-002113	Bone Cancer	CCLE	PPAAQVAPI	DEG_SIAH_1	0.3056
p.V170M	EW-13	bone	COSMIC	PPAAQVAPI	DEG_SIAH_1	0.3056
p.P168H	TCGA-85-8355	LUSC	TCGA	PPAAQVAPI	DEG_SIAH_1	0.7694
p.P168H	DO45488	LUSC	ICGC	PPAAQVAPI	DEG_SIAH_1	0.7694
p.N174K	TCGA-L9-A5IP	LUAD	TCGA	PPAAQVAPI	DEG_SIAH_1	0.1944
p.N174K	DO49873	LUAD	ICGC	PPAAQVAPI	DEG_SIAH_1	0.1944
p.A175T	DO233884	GACA	ICGC	PPAAQVAPI	DEG_SIAH_1	0.1667
p.P172S	DO231049	LUSC	ICGC	PPAAQVAPI	DEG_SIAH_1	0.25
p.P177L	DO27779	MALY	ICGC	PPAAQVAPI	DEG_SIAH_1	0.1111
p.W178C	DO229224	THCA	ICGC	PPAAQVAPI	DEG_SIAH_1	0.0833
p.N174Y	DO229100	UTCA	ICGC	PPAAQVAPI	DEG_SIAH_1	0.1944
p.P172L	SIDM01112	Osteosarcoma	GDSC	PPAAQVAPI	DEG_SIAH_1	0.25
p.P172L	SJSA-1	bone	COSMIC	PPAAQVAPI	DEG_SIAH_1	0.25
p.S171F	SIDM00516	Melanoma	GDSC	PPAAQVAPI	DEG_SIAH_1	0.2778
p.S171F	ACH-002166	Skin Cancer	CCLE	PPAAQVAPI	DEG_SIAH_1	0.2778
p.S171F	MZ7-mel	skin	COSMIC	PPAAQVAPI	DEG_SIAH_1	0.2778
p.G154V	ACH-000953	Leukemia	CCLE	PPAAQVAPI	DEG_SIAH_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons