DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PPATPRLE
Uniprot ID:
A6NNL0
Source protein:
NUT family member 2B
Source gene:
NUTM2B
Class:
DEG_SCF_FBW7_2
Location:
430:437
E3 ligase:
FBXW7
DEGRON score:
0.9102
ASA_SCORE:
92.3
COIL:
0.9526
CONS_SCORE:
0.6261
DSS_SCORE:
0.6766
HELIX:
0.017
FCONS_SCORE:
1.0298
RIG_SCORE:
0.6113
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NUTM2B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPATPRLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NNL0
NUT family member 2B
DEG_SCF_FBW7_2
430:437
PPATPRLE
FBXW7
0.9102
More...
B1AL46
NUT family member 2E
DEG_SCF_FBW7_2
430:437
PPATPRLE
FBXW7
0.827
More...
Q5VT03
NUT family member 2D
DEG_SCF_FBW7_2
358:365
PPATPRLE
FBXW7
0.8456
More...
Q8IVF1
NUT family member 2A
DEG_SCF_FBW7_2
430:437
PPATPRLE
FBXW7
0.9102
More...