DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PQTTS
Uniprot ID:
D6RIA3
Source protein:
Uncharacterized protein C4orf54
Source gene:
C4orf54
Class:
DEG_SPOP_SBC_1
Location:
59:63
E3 ligase:
SPOP
DEGRON score:
0.5973
ASA_SCORE:
87.26
COIL:
0.8436
CONS_SCORE:
0.6537
DSS_SCORE:
0.5893
HELIX:
0.0632
FCONS_SCORE:
1.1792
RIG_SCORE:
0.6437
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S73F
SIDM00006
Other Solid Cancers
GDSC
PQTTS
DEG_SPOP_SBC_1
0.0556
Drug responses associated with C4orf54 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14154
DAP3-binding cell death enhancer 1
DEG_SPOP_SBC_1
33:37
PQTTS
SPOP
0.733
More...
D6RIA3
Uncharacterized protein C4orf54
DEG_SPOP_SBC_1
59:63
PQTTS
SPOP
0.5973
More...