DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PQTTS
Uniprot ID:
Q14154
Source protein:
DAP3-binding cell death enhancer 1
Source gene:
DELE1
Class:
DEG_SPOP_SBC_1
Location:
33:37
E3 ligase:
SPOP
DEGRON score:
0.733
ASA_SCORE:
74.02
COIL:
0.8264
CONS_SCORE:
0.3799
DSS_SCORE:
0.7381
HELIX:
0.0932
FCONS_SCORE:
0.9156
RIG_SCORE:
0.6235
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DELE1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14154
DAP3-binding cell death enhancer 1
DEG_SPOP_SBC_1
33:37
PQTTS
SPOP
0.733
More...
D6RIA3
Uncharacterized protein C4orf54
DEG_SPOP_SBC_1
59:63
PQTTS
SPOP
0.5973
More...