DegronMD

Uniprot ID: Q5VV16

Source protein: Forkhead box protein D4-like 5

Source gene: FOXD4L5

Class: DEG_SCF_FBW7_1

Location: 9:16

E3 ligase: FBXW7

DEGRON score: 0.8478

ASA_SCORE: 97.95

COIL: 0.9168

CONS_SCORE: 0.395

DSS_SCORE: 0.794

HELIX: 0.0376

FCONS_SCORE: 0.9044

RIG_SCORE: 0.5928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4S	TCGA-AP-A0LM	UCEC	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.1944
p.P4S	DO43306	UCEC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.1944
p.T12I	TCGA-BR-6566	STAD	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.7078
p.T12I	DO38217	STAD	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.7078
p.G25S	TCGA-EY-A215	UCEC	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.0833
p.G25S	DO42665	UCEC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.0833
p.L3M	DO50987	LAML	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.L3M	DO231184	LAML	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.L3M	DO224594	LUSC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.L3M	DO52369	LUSC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.R15H	SIDM01112	Osteosarcoma	GDSC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	H513	pleura	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	A2780	ovary	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	TE-441-T	soft_tissue	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	DOV13	ovary	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	SJSA-1	bone	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	HCC-15	lung	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	ZR-75-30	breast	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons