DegronMD

Uniprot ID: Q9NU39

Source protein: Forkhead box protein D4-like 1

Source gene: FOXD4L1

Class: DEG_SCF_FBW7_1

Location: 9:16

E3 ligase: FBXW7

DEGRON score: 0.9176

ASA_SCORE: 104.5

COIL: 0.936

CONS_SCORE: 0.316

DSS_SCORE: 0.7934

HELIX: 0.0283

FCONS_SCORE: 0.7228

RIG_SCORE: 0.5928

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13L	SIDM01951	Colorectal Carcinoma	GDSC	PRSTPQRS	DEG_SCF_FBW7_1	0.7582
p.R15C	TCGA-AP-A1DK	UCEC	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.719
p.R15C	DO42033	UCEC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.719
p.P9L	DO229013	COCA	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.6471
p.P9L	DO229003	COCA	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.6471
p.P9L	DO51035	LAML	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.6471
p.R8H	TCGA-FA-A7Q1	DLBC	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8H	DO219890	DLBC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8H	SIDM00789	Colorectal Carcinoma	GDSC	PRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8H	ACH-000997	Colon/Colorectal Cancer	CCLE	PRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8H	HCT-15	large_intestine	COSMIC	PRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8G	SIDM01018	Hodgkin's Lymphoma	GDSC	PRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R18Q	TCGA-BR-8591	STAD	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.R18Q	DO47973	STAD	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.G22E	TCGA-A5-A0G2	UCEC	TCGA	PRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.G22E	DO41235	UCEC	ICGC	PRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.G22E	SIDM01060	Melanoma	GDSC	PRSTPQRS	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons