DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRSTPQRS
Uniprot ID:
Q8WXT5
Source protein:
Forkhead box protein D4-like 4
Source gene:
FOXD4L4
Class:
DEG_SCF_FBW7_1
Location:
9:16
E3 ligase:
FBXW7
DEGRON score:
0.8479
ASA_SCORE:
100.8875
COIL:
0.9158
CONS_SCORE:
0.3951
DSS_SCORE:
0.794
HELIX:
0.0424
FCONS_SCORE:
0.9057
RIG_SCORE:
0.5928
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D21N
SIDM01951
Colorectal Carcinoma
GDSC
PRSTPQRS
DEG_SCF_FBW7_1
0.1944
Drug responses associated with FOXD4L4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRSTPQRS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NU39
Forkhead box protein D4-like 1
DEG_SCF_FBW7_1
9:16
PRSTPQRS
FBXW7
0.9176
More...
Q8WXT5
Forkhead box protein D4-like 4
DEG_SCF_FBW7_1
9:16
PRSTPQRS
FBXW7
0.8479
More...
Q5VV16
Forkhead box protein D4-like 5
DEG_SCF_FBW7_1
9:16
PRSTPQRS
FBXW7
0.8478
More...