DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 4011:4017

E3 ligase: FBXW7

DEGRON score: 0.8611

ASA_SCORE: 97.7571

COIL: 0.9104

CONS_SCORE: 0.7817

DSS_SCORE: 0.5659

HELIX: 0.0144

FCONS_SCORE: 1.1772

RIG_SCORE: 0.6768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4012N	TCGA-B7-A5TI	STAD	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.5958
p.S4012N	DO222328	STAD	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.5958
p.G4020D	TCGA-CV-7568	HNSC	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.25
p.G4020D	DO14160	HNSC	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.25
p.R4019I	TCGA-FI-A2D5	UCEC	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.2778
p.R4019I	DO41331	UCEC	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.2778
p.T4027M	DO229022	LICA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.0556
p.T4003A	SIDM00499	Prostate Carcinoma	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.1111
p.T4003A	ACH-000956	Prostate Cancer	CCLE	PSTPRTT	DEG_SCF_FBW7_1	0.1111
p.T4003A	22RV1	prostate	COSMIC	PSTPRTT	DEG_SCF_FBW7_1	0.1111
p.T4027A	SIDM00498	Colorectal Carcinoma	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.0556
p.T4027A	ACH-000970	Colon/Colorectal Cancer	CCLE	PSTPRTT	DEG_SCF_FBW7_1	0.0556
p.T4027A	SNU-C5	large_intestine	COSMIC	PSTPRTT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons