DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 2249:2255

E3 ligase: FBXW7

DEGRON score: 0.9917

ASA_SCORE: 97.3857

COIL: 0.9373

CONS_SCORE: 0.1905

DSS_SCORE: 0.5129

HELIX: 0.0149

FCONS_SCORE: 1.0211

RIG_SCORE: 0.6467

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2251M	TCGA-EA-A439	CESC	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.7423
p.T2251M	DO44297	CESC	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.7423
p.T2251M	DO233784	GACA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.7423
p.P2249L	ACH-001685	Lymphoma	CCLE	PSTPRTT	DEG_SCF_FBW7_1	0.6471
p.S2250C	DO233101	GACA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.643
p.A2256T	DO227745	COCA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.3056
p.A2247V	TCGA-XF-A8HE	BLCA	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.2778
p.A2247V	DO49797	BLCA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.2778
p.I2246N	DO228562	LICA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.25
p.I2246N	DO228807	LICA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.25
p.T2245S	DO223097	ESCA	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.2222
p.S2244G	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.1944
p.S2244G	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.1944
p.S2244G	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRTT	DEG_SCF_FBW7_1	0.1944
p.A2261T	TCGA-AX-A3FT	UCEC	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	TCGA-CV-5435	HNSC	TCGA	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	DO14299	HNSC	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	DO40801	UCEC	ICGC	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	SIDM01612	Endometrial Carcinoma	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	ACH-000946	Endometrial/Uterine Cancer	CCLE	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	ACH-001991	Primary	CCLE	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2261T	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRTT	DEG_SCF_FBW7_1	0.1667
p.A2242V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PSTPRTT	DEG_SCF_FBW7_1	0.1389
p.A2242V	ACH-000797	Non-Cancerous	CCLE	PSTPRTT	DEG_SCF_FBW7_1	0.1389

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Drug responses associated with MUC6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSTPRTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	4011:4017	PSTPRTT	FBXW7	0.8611	More...
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	2249:2255	PSTPRTT	FBXW7	0.9917	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPRTT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PSTPRTT