DegronMD

Uniprot ID: Q5T5Y3

Source protein: Calmodulin-regulated spectrin-associated protein 1

Source gene: CAMSAP1

Class: DEG_SCF_FBW7_2

Location: 1123:1128

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 99.3833

COIL: 0.9502

CONS_SCORE: 0.3918

DSS_SCORE: 0.7781

HELIX: 0.0277

FCONS_SCORE: 0.9947

RIG_SCORE: 0.5751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1119G	TCGA-61-2113	OV	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.2222
p.R1119G	DO29328	OV	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.2222
p.S1126N	TCGA-66-2770	LUSC	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.5958
p.S1126N	DO27556	LUSC	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.5958
p.R1119Q	TCGA-AG-A002	READ	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.2222
p.R1119Q	TCGA-AX-A2HC	UCEC	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.2222
p.R1119Q	DO41572	UCEC	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.2222
p.T1129M	TCGA-DU-6392	LGG	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.3056
p.T1129M	DO22237	LGG	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.3056
p.T1129M	DO35210	PACA	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.3056
p.P1137S	TCGA-EE-A29E	SKCM	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.0833
p.P1137S	DO37831	SKCM	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.0833
p.P1131S	TCGA-EM-A3FK	THCA	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.25
p.P1131S	DO48064	THCA	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.25
p.Q1115H	TCGA-FI-A2D5	UCEC	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.1111
p.Q1115H	DO41331	UCEC	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.1111
p.P1137L	TCGA-QH-A6CW	LGG	TCGA	PTPSVE	DEG_SCF_FBW7_2	0.0833
p.P1137L	DO50170	LGG	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.0833
p.T1124M	DO234444	ESAD	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.8534
p.R1113M	DO231141	LUSC	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.0556
p.S1117F	DO220906	MELA	ICGC	PTPSVE	DEG_SCF_FBW7_2	0.1667
p.P1137A	SIDM01123	Prostate Carcinoma	GDSC	PTPSVE	DEG_SCF_FBW7_2	0.0833
p.P1137A	ACH-000177	Prostate Cancer	CCLE	PTPSVE	DEG_SCF_FBW7_2	0.0833
p.P1137A	NCI-H660	prostate	COSMIC	PTPSVE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SCF_FBW7_2	1123:1128	PTPSVE	FBXW7	0.9929	More...
Q96HH9	GRAM domain-containing protein 2B	DEG_SCF_FBW7_2	50:55	PTPSVE	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons