DegronMD

Uniprot ID: Q96HH9

Source protein: GRAM domain-containing protein 2B

Source gene: GRAMD2B

Class: DEG_SCF_FBW7_2

Location: 50:55

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 102.4833

COIL: 0.9387

CONS_SCORE: 0.5024

DSS_SCORE: 0.6955

HELIX: 0.0418

FCONS_SCORE: 1.1384

RIG_SCORE: 0.6393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K54N	SIDM00327	Hodgkin's Lymphoma	GDSC	PTPSVE	DEG_SCF_FBW7_2	0.6918
p.K54N	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSVE	DEG_SCF_FBW7_2	0.6918
p.A56V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSVE	DEG_SCF_FBW7_2	0.3056
p.R50W	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSVE	DEG_SCF_FBW7_2	0.8634
p.A40V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSVE	DEG_SCF_FBW7_2	0.1667
p.R50Q	Mewo	skin	COSMIC	PTPSVE	DEG_SCF_FBW7_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SCF_FBW7_2	1123:1128	PTPSVE	FBXW7	0.9929	More...
Q96HH9	GRAM domain-containing protein 2B	DEG_SCF_FBW7_2	50:55	PTPSVE	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons