DegronMD

Uniprot ID: A8TX70

Source protein: Collagen alpha-5

Source gene: COL6A5

Class: DEG_APCC_KENBOX_2

Location: 267:271

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8315

ASA_SCORE: 80.42

COIL: 0.9184

CONS_SCORE: 0.5438

DSS_SCORE: 0.2237

HELIX: 0.019

FCONS_SCORE: 0.9552

RIG_SCORE: 0.8683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L258I	TCGA-A6-5661	COAD	TCGA	VKENC	DEG_APCC_KENBOX_2	0.0833
p.L258I	DO8634	COAD	ICGC	VKENC	DEG_APCC_KENBOX_2	0.0833
p.Y279S	TCGA-AA-A010	COAD	TCGA	VKENC	DEG_APCC_KENBOX_2	0.1111
p.M277V	TCGA-EY-A2OM	UCEC	TCGA	VKENC	DEG_APCC_KENBOX_2	0.1667
p.M277V	DO43025	UCEC	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1667
p.M272L	DO225112	BRCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.3056
p.R273Q	DO222884	COCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.2778
p.R273Q	DO33800	PACA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.2778
p.R273Q	ACH-000100	Sarcoma	CCLE	VKENC	DEG_APCC_KENBOX_2	0.2778
p.R273Q	ACH-001765	Sarcoma	CCLE	VKENC	DEG_APCC_KENBOX_2	0.2778
p.S263C	DO228937	LICA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.2222
p.C271R	DO45237	LIRI	ICGC	VKENC	DEG_APCC_KENBOX_2	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8TX70	Collagen alpha-5	DEG_APCC_KENBOX_2	267:271	VKENC	APC,CDC20,FZR1	0.8315	More...
P53794	Sodium/myo-inositol cotransporter	DEG_APCC_KENBOX_2	554:558	VKENC	APC,CDC20,FZR1	0.7879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons