DegronMD

Uniprot ID: P53794

Source protein: Sodium/myo-inositol cotransporter

Source gene: SLC5A3

Class: DEG_APCC_KENBOX_2

Location: 554:558

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7879

ASA_SCORE: 92.08

COIL: 0.7222

CONS_SCORE: 0.2122

DSS_SCORE: 0.369

HELIX: 0.156

FCONS_SCORE: 0.9409

RIG_SCORE: 0.7852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N551I	TCGA-A6-3807	COAD	TCGA	VKENC	DEG_APCC_KENBOX_2	0.25
p.N551I	DO9034	COAD	ICGC	VKENC	DEG_APCC_KENBOX_2	0.25
p.Q566P	TCGA-CA-6718	COAD	TCGA	VKENC	DEG_APCC_KENBOX_2	0.1111
p.Q566P	DO7801	COAD	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1111
p.Q568K	TCGA-GM-A3XL	BRCA	TCGA	VKENC	DEG_APCC_KENBOX_2	0.0556
p.Q568K	DO44111	BRCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.0556
p.Q566K	DO229010	COCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1111
p.Q566K	DO229013	COCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1111
p.Q566K	DO229016	COCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1111
p.Q566K	DO229003	COCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1111
p.Q566K	DO229005	COCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1111
p.W547C	DO228948	LICA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.1389
p.E556K	DO48909	PBCA	ICGC	VKENC	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8TX70	Collagen alpha-5	DEG_APCC_KENBOX_2	267:271	VKENC	APC,CDC20,FZR1	0.8315	More...
P53794	Sodium/myo-inositol cotransporter	DEG_APCC_KENBOX_2	554:558	VKENC	APC,CDC20,FZR1	0.7879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons