DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VSLFDD
Uniprot ID:
Q641Q2
Source protein:
WASH complex subunit 2A
Source gene:
WASHC2A
Class:
LIG_APCC_ABBA_1
Location:
570:575
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9933
ASA_SCORE:
78.6167
COIL:
0.8398
CONS_SCORE:
0.4314
DSS_SCORE:
0.3679
HELIX:
0.0672
FCONS_SCORE:
1.0235
RIG_SCORE:
0.8061
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N581T
SIDM01611
Endometrial Carcinoma
GDSC
VSLFDD
LIG_APCC_ABBA_1
0.1667
Drug responses associated with WASHC2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSLFDD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q641Q2
WASH complex subunit 2A
LIG_APCC_ABBA_1
570:575
VSLFDD
APC,CDC20,FZR1
0.9933
More...
Q9Y4E1
WASH complex subunit 2C
LIG_APCC_ABBA_1
570:575
VSLFDD
APC,CDC20,FZR1
0.9854
More...