DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VSLFDD
Uniprot ID:
Q9Y4E1
Source protein:
WASH complex subunit 2C
Source gene:
WASHC2C
Class:
LIG_APCC_ABBA_1
Location:
570:575
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9854
ASA_SCORE:
77.0167
COIL:
0.84
CONS_SCORE:
0.3811
DSS_SCORE:
0.4791
HELIX:
0.0775
FCONS_SCORE:
0.9738
RIG_SCORE:
0.7484
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with WASHC2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSLFDD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q641Q2
WASH complex subunit 2A
LIG_APCC_ABBA_1
570:575
VSLFDD
APC,CDC20,FZR1
0.9933
More...
Q9Y4E1
WASH complex subunit 2C
LIG_APCC_ABBA_1
570:575
VSLFDD
APC,CDC20,FZR1
0.9854
More...