Gene: Tns1

Basic information

Tag Content
Uniprot ID A0A087WQ94
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSMUSP00000140094
Ensembl nucleotide ID ENSMUSG00000055322
Gene name Tensin 1
Gene symbol Tns1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
XNTSVSRAME DSCELDLVYV TERIIAVSFP STANEENFRS NLREVAQMLK SKHGGNYLLF 60
NLSEQRPDIT KLHAKVLEFG WPDLHTPALE KICSVCKAMD TWLNADPHNV VVLHNKGNRG 120
RIGVVIAAYL HYSNISASAD QALDRFAMKR FYEDKIVPIG QPSQRRYVHY FSGLLSGSIK 180
MNNKPLFLHH VIMHGIPNFE SKGGCRPFLR IYQAMQPVYT SGIYNIPGDS QASICITIEP 240
GLLLKGDILL KCYHKKFRSP ARDVIFRVQF HTCAIHDLGV VFGKEDLDEA FKDDRFPDYG 300
KVEFVFSYGP EKIQGMEHLE NGPSVSVDYN TSDPLIRWDS YDNFSGHRED GMEEVVGHTQ 360
GPLDGSLYAK VKKKDSLNGS SGPVTTARPA LSATPNHVEH TLSVSSDSGN STASTKTDKT 420
DEPVSGATTA PAALSPQEKK ELDRLLSGFG VDREKQGAMY RAQQLRSHPG GGPTVPSPGR 480
HIVPAQVHVN GGALASERET DILDDELPIQ DGQSGGSMGT LSSLDGVTNT SESGYPETLS 540
PLTNGLDKPY STEPVLNGGG YPYEAANRVI PVHSSHSAPI RPSYSAQEGL AGYQREGPHP 600
AWSQQVTSAH CGCDPSGLFR SQSFPDVEPQ LPQAPTRGGS SREAVQRGLN SWQQQQPHPP 660
PRQQERSPLQ SLARSKPSPQ LSAETPVAAL PEFPRAASQQ EIEQSIETLN MLMLDLEPAS 720
AAAPLHKSQS VPGAWPGASP LSSQPLLGSS RQSHPLTQSR SGYIPSGHSL GTPELVSSGR 780
PYSPYDYQLH PAGSNQSFHP KSPASSTFLP SPHSSAGPQE PPASLPGLIA QPQLPPKETT 840
SDPSRTPEEE PLNLEGLVAH RVAGVQARER QPAEPPGPLR RRAASDGQYE NQSPEATSPR 900
SPGVRSPVQC VSPELALTIA LNPGGRPKEP HLHSYKEAFE EMEGTSPSSP PHSVARSPPG 960
LAKTPLSALG LKPHNPADIL LHPTGVARRL IQPEEDEGEE VTKPPEEPRS YVESVARTAV 1020
AGPRAQDVEP KSFSAPAAHA YGHETPLRNG TPGGSFVSPS PLSTSSPILS ADSTSVGSFP 1080
SVVSSDQGPR TPFQPMLDSS IRSGSLGQPS PAALSYQSSS PVPVGGSSYN SPDYSLQPFS 1140
SSPESQGQPQ YSAASVHMVP GSPQARHRTV GTNTPPSPGF GRRAVNPTMA APGSPSLSHR 1200
QVMGPSGPGF HGNVVSGHPA SAATTPGSPS LGRHPVGSHQ VPGLHSSVVT TPGSPSLGRH 1260
PGAHQGNLAS SLHSNAVISP GSPSLGRHLG GSGSVVPGSP SLDRHAAYGG YSTPEDRRPT 1320
LSRQSSASGY QAPSTPSFPV SPAYYPGLSS PATSPSPDSA AFRQGSPTPA LPEKRRMSVG 1380
DRAGSLPNYA TINGKVSSSP VANGMASGSS TVSFSHTLPD FSKYSMPDNS PETRAKVKFV 1440
QDTSKYWYKP EISREQAIAL LKDQEPGAFI IRDSHSFRGA YGLAMKVSSP PPTITQQGKK 1500
GDMTHELVRH FLIETGPRGV KLKGCPNEPN FGSLSALVYQ HSVIPLALPC KLVIPSRDPT 1560
DESKDSSGPA NSTTDLLKQG AACNVLFVNS VDMESLTGPQ AISKATSETL AADPTPAATI 1620
VHFKVSAQGI TLTDNQRKLF FRRHYPLNTV TFCDLDPQER KWMKTEGGAP AKLFGFVARK 1680
QGSTTDNACH LFAELDPNQP ASAIVNFVSK VMLSAGQKR 1719

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTNS1A0A452EMY6Capra hircusPredictionMore>>
1:1 orthologTNS17145Q9HBL0Homo sapiensPublicationMore>>
1:1 orthologTns1A0A087WQ94Mus musculusPredictionMore>>
1:1 orthologTNS1459934A0A2I3SUI0Pan troglodytesPredictionMore>>
1:1 orthologTns1301509F1LN42Rattus norvegicusPredictionMore>>
1:1 orthologtns1bF1Q649Danio rerioPredictionMore>>

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0727 SH2 domain

Interpro

InterPro ID InterPro Term
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035012 Tensin-like_SH2
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat

PROSITE

PROSITE ID PROSITE Term
PS51182 C2_TENSIN
PS51181 PPASE_TENSIN
PS50001 SH2

Pfam

Pfam ID Pfam Term
PF08416 PTB
PF10409 PTEN_C2
PF00017 SH2

Protein-miRNA interaction