Gene: TNS1

Basic information

Tag Content
Uniprot ID A0A2I3SUI0
Entrez ID 459934
Genbank protein ID
Genbank nucleotide ID XM_016950476.1; XM_016950470.1;
Ensembl protein ID ENSPTRP00000080648
Ensembl nucleotide ID ENSPTRG00000012906
Gene name Tensin 1
Gene symbol TNS1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSVSRTMEDS CELDLVYVTE RIIAVSFPST ANEENFRSNL REVAQMLKSK HGGNYLLFNL 60
SERRPDITKL HAKVLEFGWP DLHTPALEKI CSICKAMDTW LNADPHNVVV LHNKGNRGRI 120
GVVIAAYMHY SNISASADQA LDRFAMKRFY EDKIVPIGQP SQRRYVHYFS GLLSGSIKMN 180
NKPLFLHHVI MHGIPNFESK GGCRPFLRIY QAMQPVYTSG IYNIPGDSQT SVCITIEPGL 240
LLKGDILLKC YHKKFRSPAR DVIFRVQFHT CAIHDLGVVF GKEDLDDAFK DDRFPEYGKV 300
EFVFSYGPEK IQGMEHLENG PSVSVDYNTS DPLIRWDSYD NFSGHRDDGM EEVVGHTQGP 360
LDGSLYAKVK KKDSLHGSTG AVNATRPTLS ATPNHVEHTL SVSSDSGNST ASTKTDKTDE 420
PVPGASSATA ALSPQEKREL DRLLSGFGLE REKQGAMYHT QHLRSRPAGG SAVPSSGRHV 480
VPAQVHVNGG ALASERETDI LDDELPNQDG HSAGSMGTLS SLDGVTNTSE GGYPEALSPL 540
TNGLDKSYPM EPMVNGGGYP YESASRAGPA HAGHTAPMRP SYSAQEGLAG YQREGPHPAW 600
PQPVTTSHYA HDPSGMFRSQ SFSEAEPQLP PAPVRGGSSR EAVQRGLNSW QQQQQQQQPR 660
PPPRQQERAH LESLVASRPS PQPLAETPIP SLPEFPRAAS QQEIEQSIET LNMLMLDLEP 720
ASAAAPLHKS QSVPGAWPGA SPLSSQPLSG SSRQSHPLTQ SRSGYIPSGH SLGTPEPAPR 780
ASLESVPPGR SYSPYDYQPC LAGPNQDFHS KSPASSSLPA FLPTTHSPPG PQQPPASLPG 840
LTAQPLLSPK EATSDPSRTP EEEPLNLEGL VAHRVAGVQA REKQPAEPPA PLRRRAASDG 900
QYENQSPEAT SPRSPGVRSP VQCVSPELAL TIALNPGGRP KEPHLHSYKE AFEEMEGTSP 960
SSPPPSGVRS PPGLAKTPLS ALGLKPHNPA DILLHPTGVT RRRIQPEEDE GKVVVRLSEE 1020
PRSYVESVAR TAVVGPRAQD SEPKSFSAPA TQAYGHEIPL RNGTLGGSFV SPSPLSTSSP 1080
ILSADSTSVG SFPSGESSDH GPRTPTQPLL ESGFRSGSLG QPSPSAQRNY QSSSPLPTVG 1140
SSYSSPDYSL QHFSSSPESQ ARAQFSVAGV HTVPGSPQAR HRTVGTNTPP SPGFGRRAIN 1200
PSMAAPSSPS LSHRQMMGPP GTGFHGSTVS SPQSSAATTP GSPSLGRHPA GAYQVSGLHN 1260
NVATTPGSPS LGRHPGAHQG NLASGLHSNA IASPGSPSLG RHLGGSGSVV PGSPCLDRHV 1320
AYGGYSTPED RRPTLSRQSS ASGYQAPSTP SFPVSPAYYP ALSSPATSPS PDSAAFRQGS 1380
PTPALPEKRR MSVGDRAGSL PNYATINGKV SSPVASGMSS PSGGSTISFS HTLPDFSKYS 1440
MPDNSPETRA KVKFVQDTSK YWYKPEISRE QAIALLKDQE PGAFIIRDSH SFRGAYGLAM 1500
KVSSPPPTIM QQNKKGDMTH ELVRHFLIET GPRGVKLKGC PNEPNFGSLS ALVYQHSIIP 1560
LALPCKLVIP NRDPTDESKD SSGPANSTAD LLKQGAACNV LFVNSVDMES LTGPQAISKA 1620
TSETLAADPT PAATIVHFKV SAQGITLTDN QRKLFFRRHY PLNTVTFCDL DPQERKWMKT 1680
EGGAPAKLFG FVARKQGSTT DNACHLFAEL DPNQPASAIV NFVSKVMLNA GQKR 1734

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTNS1A0A452EMY6Capra hircusPredictionMore>>
1:1 orthologTNS17145Q9HBL0Homo sapiensPublicationMore>>
1:1 orthologTns1A0A087WQ94Mus musculusPredictionMore>>
1:1 orthologTNS1459934A0A2I3SUI0Pan troglodytesPredictionMore>>
1:1 orthologTns1301509F1LN42Rattus norvegicusPredictionMore>>
1:1 orthologtns1bF1Q649Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0727 SH2 domain

Interpro

InterPro ID InterPro Term
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035012 Tensin-like_SH2
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat

PROSITE

PROSITE ID PROSITE Term
PS51182 C2_TENSIN
PS51181 PPASE_TENSIN
PS50001 SH2

Pfam

Pfam ID Pfam Term
PF08416 PTB
PF10409 PTEN_C2
PF00017 SH2