| Tag | Content |
|---|---|
| Uniprot ID | A0A096MJ70 |
| Entrez ID | 100366024 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_017593881.1 |
| Ensembl protein ID | ENSRNOP00000068014 |
| Ensembl nucleotide ID | ENSRNOG00000045913 |
| Gene name | PR/SET domain 16 |
| Gene symbol | Prdm16 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MCQINEQIYY KVIKDIEPGE ELLVHVKEGA YSLGVMAPSL DEDPTFRCDE CDELFQCRLD 60 LRRHKKYACS SSGAPLYEGL GEELKPEGLG GGNDGQAHEC KDCERMFPNK YSLEQHMIVH 120 TEEREYKCDQ CPKAFNWKSN LIRHQMSHDS GKRFECENCV KVFTDPSNLQ RHIRSQHVGA 180 RAHACPDCGK TFATSSGLKQ HKHIHSTVKP FICEVCHKSY TQFSNLCRHK RMHADCRTQI 240 KCKDCGQMFS TTSSLNKHRR FCEGKNHYTP GGLFTPGLPL TPSPMMDKTK PSPTLNHGGL 300 GFSEYFPSRP HPGSLPFSAA PPAFPTLTPG FPGIFPPSLY PRPPLLPPTP LLKSPLNHGQ 360 DAKLHSPLGN PALPLVSAVS NSSQGATAAT GPEEKFDGRL EDSYVEKVKN RSPDMSDGSD 420 FEDINTTTGT DLDTTTGTGS DLDSDLDSDR DKSKDKGKPA ESKPEFGGAS VPPGAMNSVA 480 EVPAFYSQHS FFPPPEEQLL TASGAAGDSI KAIASIAEKY FGPGFMSMQE KKLGSLPYHS 540 VFPFQFLPNF PHSLYPFTDR ALAHNLLVKA EPKSPRDALK VGGPSAECPF DLTTKPKEAK 600 PALLTPKAPL VPSSGEEQPL DLSIGSRARA SQNGGSREPR KNHIYGERKP GVGEGLPKVC 660 PAQLPQQPSL HYAKPSPFFM DPIYSRVEKR KVADPVGVLK EKYLRPSPLL FHPQMSAIET 720 MTEKLESFAA MKADSGSSLQ PLPHHPFNFR SPPPTLSDPI LRKGKERYTC RYCGKIFPRS 780 ANLTRHLRTH TGEQPYRCKY CDRSFSISSN LQRHVRNIHN KEKPFKCHLC NRCFGQQTNL 840 DRHLKKHEHE GAPVSQHSGV LTNHLGTSAS SPTSESDNHA LLDEKEDSYF SEIRNFIANS 900 EMNQASTRMD KRPEVQDLDG NPPCPGSASA KQEDVEEEEE EELEEEDDDS LAGKSQEDTV 960 SPTPEPQGVY EDEEDEEPPN LTMDFDHTRR CVEERGGGLL ALEPTPTFGK GLDLRRAAEE 1020 AFEVKDVLNS TLDSEVLKQT LYRQAKNQAY AMMLSLSEDT PLHAPSQSSL DAWLNITGPS 1080 SESGAFNPIN HL 1092 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRDM16 | A0A452F1P6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PRDM16 | 63976 | Q9HAZ2 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prdm16 | 70673 | A2A935 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PRDM16 | 457227 | H2R9K2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Prdm16 | 100366024 | A0A096MJ70 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | prdm16 | B8JHX5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0017053 | transcriptional repressor complex |
| GO:0033613 | activating transcription factor binding |
| GO:0046974 | histone methyltransferase activity (H3-K9 specific) |
| GO:0043565 | sequence-specific DNA binding |
| GO:0046332 | SMAD binding |
| GO:0003713 | transcription coactivator activity |
| GO:0003712 | transcription coregulator activity |
| GO:0050873 | brown fat cell differentiation |
| GO:0070828 | heterochromatin organization |
| GO:0030853 | negative regulation of granulocyte differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0022008 | neurogenesis |
| GO:0090336 | positive regulation of brown fat cell differentiation |
| GO:0120162 | positive regulation of cold-induced thermogenesis |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0043457 | regulation of cellular respiration |
| GO:0010468 | regulation of gene expression |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0060021 | roof of mouth development |
| GO:0035019 | somatic stem cell population maintenance |
| GO:0019827 | stem cell population maintenance |
| GO:0043586 | tongue development |
| GO:0050872 | white fat cell differentiation |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |