| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JSK5 |
| Entrez ID | 24511 |
| Genbank protein ID | EDL96787.1 |
| Genbank nucleotide ID | NM_017022.2 |
| Ensembl protein ID | ENSRNOP00000014785 |
| Ensembl nucleotide ID | ENSRNOG00000010966 |
| Gene name | Integrin beta |
| Gene symbol | Itgb1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MNLQLVFWIG LISLICSVFG QTDKNRCLKA NAKSCGECIQ AGPNCGWCTN TTFLQEGMPT 60 SARCDDLEAL KKKGCQPSDI ENPRGSQTIK KNKNVTNRSK GMAEKLRPED ITQIQPQQLL 120 LKLRSGEPQK FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180 RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTDRGE FFNELVGQQR 240 ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300 CHLENNVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360 SGNSSNVIQL IIDAYNSLSS EVILENSKLP DGVTINYKSY CKNGVNGTGE NGRKCSNISI 420 GDEVQFEISI TANKCPNKES ETIKIKPLGF TEEVEVVLQF ICKCNCQSHG IPASPKCHEG 480 NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540 RENTNEIYSG KFCECDNFNC DRSNGLICGG NGVCRCRVCE CYPNYTGSAC DCSLDTVPCV 600 ATNGQICNGR GICECGACKC TDPKFQGPTC ETCQTCLGVC AEHKECVQCR AFNKGEKKDT 660 CAQECSHFNL TKVESREKLP QPVQVDPVTH CKEKDIDDCW FYFTYSVNSN GEAHVHVVET 720 PDCPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 780 PIYKSAVTTV VNPKYEGK 798 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB1 | 102178060 | A0A452E668 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB1 | 3688 | P05556 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb1 | 16412 | P09055 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGB1 | 450396 | A0A2J8MN19 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ITGB1 | 100008898 | A0A5F9C3C4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgb1 | 24511 | A0A0G2JSK5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0031410 | cytoplasmic vesicle |
| GO:0043197 | dendritic spine |
| GO:0009897 | external side of plasma membrane |
| GO:0030175 | filopodium |
| GO:0005925 | focal adhesion |
| GO:0098978 | glutamatergic synapse |
| GO:0099699 | integral component of synaptic membrane |
| GO:0034665 | integrin alpha1-beta1 complex |
| GO:0034680 | integrin alpha10-beta1 complex |
| GO:0034681 | integrin alpha11-beta1 complex |
| GO:0034666 | integrin alpha2-beta1 complex |
| GO:0034667 | integrin alpha3-beta1 complex |
| GO:0034674 | integrin alpha5-beta1 complex |
| GO:0034677 | integrin alpha7-beta1 complex |
| GO:0014704 | intercalated disc |
| GO:0071438 | invadopodium membrane |
| GO:0045121 | membrane raft |
| GO:0035748 | myelin sheath abaxonal region |
| GO:0031594 | neuromuscular junction |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0032587 | ruffle membrane |
| GO:0042383 | sarcolemma |
| GO:0098685 | Schaffer collateral - CA1 synapse |
| GO:0003779 | actin binding |
| GO:0019960 | C-X3-C chemokine binding |
| GO:0098639 | collagen binding involved in cell-matrix adhesion |
| GO:0001968 | fibronectin binding |
| GO:0005178 | integrin binding |
| GO:0043236 | laminin binding |
| GO:0002020 | protease binding |
| GO:0046982 | protein heterodimerization activity |
| GO:1990782 | protein tyrosine kinase binding |
| GO:0038023 | signaling receptor activity |
| GO:0048675 | axon extension |
| GO:0071711 | basement membrane organization |
| GO:0007161 | calcium-independent cell-matrix adhesion |
| GO:0055007 | cardiac muscle cell differentiation |
| GO:0023035 | CD40 signaling pathway |
| GO:0001708 | cell fate specification |
| GO:0002042 | cell migration involved in sprouting angiogenesis |
| GO:0033631 | cell-cell adhesion mediated by integrin |
| GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| GO:0048813 | dendrite morphogenesis |
| GO:0000132 | establishment of mitotic spindle orientation |
| GO:0021943 | formation of radial glial scaffolds |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0008354 | germ cell migration |
| GO:0034113 | heterotypic cell-cell adhesion |
| GO:0001701 | in utero embryonic development |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0050901 | leukocyte tethering or rolling |
| GO:0048333 | mesodermal cell differentiation |
| GO:2000811 | negative regulation of anoikis |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0035024 | negative regulation of Rho protein signal transduction |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0010763 | positive regulation of fibroblast migration |
| GO:0051951 | positive regulation of glutamate uptake involved in transmission of nerve impulse |
| GO:0043547 | positive regulation of GTPase activity |
| GO:0051897 | positive regulation of protein kinase B signaling |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:2000273 | positive regulation of signaling receptor activity |
| GO:0090303 | positive regulation of wound healing |
| GO:0150103 | reactive gliosis |
| GO:0031623 | receptor internalization |
| GO:0051726 | regulation of cell cycle |
| GO:0010710 | regulation of collagen catabolic process |
| GO:1901979 | regulation of inward rectifier potassium channel activity |
| GO:0150003 | regulation of spontaneous synaptic transmission |
| GO:0045214 | sarcomere organization |
| GO:0008542 | visual learning |
| InterPro ID | InterPro Term |
|---|---|
| IPR013111 | EGF_extracell |
| IPR040622 | I-EGF_1 |
| IPR027071 | Integrin_beta-1 |
| IPR033760 | Integrin_beta_N |
| IPR015812 | Integrin_bsu |
| IPR014836 | Integrin_bsu_cyt_dom |
| IPR012896 | Integrin_bsu_tail |
| IPR036349 | Integrin_bsu_tail_dom_sf |
| IPR002369 | Integrin_bsu_VWA |
| IPR032695 | Integrin_dom_sf |
| IPR016201 | PSI |
| IPR036465 | vWFA_dom_sf |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00243 | INTEGRIN_BETA |