| Tag | Content |
|---|---|
| Uniprot ID | P09055; F6R105; Q3TIW5; Q3TWH6; Q60993; Q61126; Q8BTU0; Q8BVU1; |
| Entrez ID | 16412 |
| Genbank protein ID | AAA80243.1; BAE39731.1; BAE35290.1; AAH50906.1; EDL11832.1; CAA33272.1; BAC40532.1; AAA88821.1; BAC36379.1; CAA68738.1; |
| Genbank nucleotide ID | NM_010578.2 |
| Ensembl protein ID | ENSMUSP00000087457 |
| Ensembl nucleotide ID | ENSMUSG00000025809 |
| Gene name | Integrin beta-1 |
| Gene symbol | Itgb1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 14522949 |
| Functional description | Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition (PubMed:12941630). Involved in promoting endothelial cell motility and angiogenesis (PubMed:15181153). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules (PubMed:21768292). May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (PubMed:18804435). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). |
| Sequence | MNLQLVSWIG LISLICSVFG QTDKNRCLKA NAKSCGECIQ AGPNCGWCTN TTFLQEGMPT 60 SARCDDLEAL KKKGCQPSDI ENPRGSQTIK KNKNVTNRSK GMAEKLRPED ITQIQPQQLL 120 LKLRSGEPQK FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180 RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTDRGE FFNELVGQQR 240 ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300 CHLENNVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360 SGNSSNVIQL IIDAYNSLSS EVILENSKLP DGVTINYKSY CKNGVNGTGE NGRKCSNISI 420 GDEVQFEISI TANKCPNKES ETIKIKPLGF TEEVEVVLQF ICKCNCQSHG IPASPKCHEG 480 NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540 RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCRCRVCE CYPNYTGSAC DCSLDTGPCL 600 ASNGQICNGR GICECGACKC TDPKFQGPTC ETCQTCLGVC AEHKECVQCR AFNKGEKKDT 660 CAQECSHFNL TKVESREKLP QPVQVDPVTH CKEKDIDDCW FYFTYSVNGN NEAIVHVVET 720 PDCPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 780 PIYKSAVTTV VNPKYEGK 798 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB1 | 102178060 | A0A452E668 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB1 | 3688 | P05556 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb1 | 16412 | P09055 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGB1 | 450396 | A0A2J8MN19 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ITGB1 | 100008898 | A0A5F9C3C4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgb1 | 24511 | A0A0G2JSK5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001968 | fibronectin binding | ISO |
| GO:0001968 | fibronectin binding | IBA |
| GO:0002020 | protease binding | ISO |
| GO:0003779 | actin binding | ISO |
| GO:0005102 | signaling receptor binding | ISO |
| GO:0005178 | integrin binding | ISO |
| GO:0005178 | integrin binding | IPI |
| GO:0005178 | integrin binding | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005518 | collagen binding | ISO |
| GO:0019900 | kinase binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0019904 | protein domain specific binding | ISO |
| GO:0038023 | signaling receptor activity | IEA |
| GO:0043236 | laminin binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO:0046982 | protein heterodimerization activity | ISS |
| GO:0046982 | protein heterodimerization activity | ISO |
| GO:0050839 | cell adhesion molecule binding | ISO |
| GO:0051393 | alpha-actinin binding | ISO |
| GO:0098639 | collagen binding involved in cell-matrix adhesion | ISO |
| GO:0098639 | collagen binding involved in cell-matrix adhesion | IBA |
| GO:1990782 | protein tyrosine kinase binding | IEA |
| GO:0019960 | C-X3-C chemokine binding | ISS |
| GO:0019960 | C-X3-C chemokine binding | ISO |
| GO:0019960 | C-X3-C chemokine binding | IBA |
| GO:0043236 | laminin binding | IDA |
| GO:0043236 | laminin binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP |
| GO:0000132 | establishment of mitotic spindle orientation | ISO |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001708 | cell fate specification | IMP |
| GO:0001894 | tissue homeostasis | ISO |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IMP |
| GO:0006909 | phagocytosis | ISO |
| GO:0007155 | cell adhesion | ISO |
| GO:0007159 | leukocyte cell-cell adhesion | ISO |
| GO:0007160 | cell-matrix adhesion | ISO |
| GO:0007160 | cell-matrix adhesion | IGI |
| GO:0007160 | cell-matrix adhesion | IMP |
| GO:0007160 | cell-matrix adhesion | IBA |
| GO:0007161 | calcium-independent cell-matrix adhesion | ISO |
| GO:0007229 | integrin-mediated signaling pathway | ISO |
| GO:0007229 | integrin-mediated signaling pathway | IBA |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | ISO |
| GO:0008284 | positive regulation of cell population proliferation | IMP |
| GO:0008285 | negative regulation of cell population proliferation | ISO |
| GO:0008354 | germ cell migration | IMP |
| GO:0008542 | visual learning | IGI |
| GO:0008542 | visual learning | IMP |
| GO:0010710 | regulation of collagen catabolic process | ISS |
| GO:0010710 | regulation of collagen catabolic process | ISO |
| GO:0010763 | positive regulation of fibroblast migration | IEA |
| GO:0010811 | positive regulation of cell-substrate adhesion | ISO |
| GO:0010976 | positive regulation of neuron projection development | ISO |
| GO:0016477 | cell migration | IBA |
| GO:0021943 | formation of radial glial scaffolds | IMP |
| GO:0023035 | CD40 signaling pathway | ISO |
| GO:0030030 | cell projection organization | ISO |
| GO:0030032 | lamellipodium assembly | ISO |
| GO:0030335 | positive regulation of cell migration | ISS |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0031175 | neuron projection development | IMP |
| GO:0031345 | negative regulation of cell projection organization | ISO |
| GO:0031589 | cell-substrate adhesion | ISO |
| GO:0031623 | receptor internalization | IDA |
| GO:0032594 | protein transport within lipid bilayer | ISO |
| GO:0033627 | cell adhesion mediated by integrin | ISS |
| GO:0033627 | cell adhesion mediated by integrin | ISO |
| GO:0033627 | cell adhesion mediated by integrin | IBA |
| GO:0033631 | cell-cell adhesion mediated by integrin | IEA |
| GO:0034113 | heterotypic cell-cell adhesion | ISO |
| GO:0035024 | negative regulation of Rho protein signal transduction | IGI |
| GO:0043065 | positive regulation of apoptotic process | ISO |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043547 | positive regulation of GTPase activity | ISO |
| GO:0045214 | sarcomere organization | IMP |
| GO:0045596 | negative regulation of cell differentiation | IMP |
| GO:0045665 | negative regulation of neuron differentiation | ISO |
| GO:0045666 | positive regulation of neuron differentiation | ISO |
| GO:0045766 | positive regulation of angiogenesis | ISO |
| GO:0045807 | positive regulation of endocytosis | ISO |
| GO:0048333 | mesodermal cell differentiation | IEA |
| GO:0048675 | axon extension | IGI |
| GO:0048675 | axon extension | IMP |
| GO:0048813 | dendrite morphogenesis | IGI |
| GO:0048813 | dendrite morphogenesis | IMP |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ISO |
| GO:0050804 | modulation of chemical synaptic transmission | IMP |
| GO:0050901 | leukocyte tethering or rolling | ISO |
| GO:0051726 | regulation of cell cycle | IMP |
| GO:0051897 | positive regulation of protein kinase B signaling | ISO |
| GO:0055007 | cardiac muscle cell differentiation | IMP |
| GO:0070830 | bicellular tight junction assembly | ISO |
| GO:0071404 | cellular response to low-density lipoprotein particle stimulus | IDA |
| GO:0071711 | basement membrane organization | IMP |
| GO:0090303 | positive regulation of wound healing | IEA |
| GO:1903078 | positive regulation of protein localization to plasma membrane | ISS |
| GO:1903078 | positive regulation of protein localization to plasma membrane | ISO |
| GO:2000273 | positive regulation of signaling receptor activity | ISO |
| GO:2000811 | negative regulation of anoikis | ISO |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IMP |
| GO:0043149 | stress fiber assembly | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001669 | acrosomal vesicle | ISO |
| GO:0005604 | basement membrane | ISO |
| GO:0005623 | cell | IEA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | TAS |
| GO:0005911 | cell-cell junction | ISO |
| GO:0005912 | adherens junction | ISO |
| GO:0005925 | focal adhesion | ISO |
| GO:0005925 | focal adhesion | ISS |
| GO:0005925 | focal adhesion | IBA |
| GO:0008305 | integrin complex | ISO |
| GO:0009897 | external side of plasma membrane | IDA |
| GO:0009986 | cell surface | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0014704 | intercalated disc | IDA |
| GO:0016020 | membrane | ISO |
| GO:0016020 | membrane | IDA |
| GO:0030027 | lamellipodium | IEA |
| GO:0030056 | hemidesmosome | ISO |
| GO:0030175 | filopodium | ISO |
| GO:0031594 | neuromuscular junction | ISO |
| GO:0031594 | neuromuscular junction | IDA |
| GO:0034665 | integrin alpha1-beta1 complex | ISO |
| GO:0034666 | integrin alpha2-beta1 complex | ISO |
| GO:0034667 | integrin alpha3-beta1 complex | ISO |
| GO:0034674 | integrin alpha5-beta1 complex | ISO |
| GO:0034677 | integrin alpha7-beta1 complex | IPI |
| GO:0034677 | integrin alpha7-beta1 complex | IDA |
| GO:0034679 | integrin alpha9-beta1 complex | ISO |
| GO:0034680 | integrin alpha10-beta1 complex | ISO |
| GO:0034681 | integrin alpha11-beta1 complex | ISO |
| GO:0035748 | myelin sheath abaxonal region | IDA |
| GO:0042383 | sarcolemma | ISO |
| GO:0042383 | sarcolemma | IDA |
| GO:0042470 | melanosome | IEA |
| GO:0043197 | dendritic spine | ISO |
| GO:0043197 | dendritic spine | IDA |
| GO:0043235 | receptor complex | ISO |
| GO:0045121 | membrane raft | ISO |
| GO:0045202 | synapse | IDA |
| GO:0045211 | postsynaptic membrane | ISO |
| GO:0055037 | recycling endosome | IEA |
| GO:0071438 | invadopodium membrane | ISS |
| GO:0071438 | invadopodium membrane | ISO |
| GO:0097060 | synaptic membrane | IDA |
| GO:0097386 | glial cell projection | ISO |
| GO:0098685 | Schaffer collateral - CA1 synapse | IMP |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0099055 | integral component of postsynaptic membrane | ISO |
| GO:0099699 | integral component of synaptic membrane | IDA |
| GO:0031410 | cytoplasmic vesicle | IDA |
| GO:0032587 | ruffle membrane | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1500931 | Cell-Cell communication | IEA |
| R-MMU-1566948 | Elastic fibre formation | IEA |
| R-MMU-1566977 | Fibronectin matrix formation | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | IEA |
| R-MMU-202733 | Cell surface interactions at the vascular wall | IEA |
| R-MMU-210991 | Basigin interactions | IEA |
| R-MMU-2129379 | Molecules associated with elastic fibres | IEA |
| R-MMU-216083 | Integrin cell surface interactions | IEA |
| R-MMU-3000157 | Laminin interactions | IEA |
| R-MMU-3000170 | Syndecan interactions | IEA |
| R-MMU-3000171 | Non-integrin membrane-ECM interactions | IEA |
| R-MMU-3000178 | ECM proteoglycans | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-445144 | Signal transduction by L1 | IEA |
| R-MMU-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | IEA |
| R-MMU-446353 | Cell-extracellular matrix interactions | IEA |
| R-MMU-446728 | Cell junction organization | IEA |
| R-MMU-6806834 | Signaling by MET | IEA |
| R-MMU-8874081 | MET activates PTK2 signaling | IEA |
| R-MMU-8875513 | MET interacts with TNS proteins | IEA |
| R-MMU-8875878 | MET promotes cell motility | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0007 | Acetylation |
| KW-0025 | Alternative splicing |
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-1015 | Disulfide bond |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-0401 | Integrin |
| KW-1017 | Isopeptide bond |
| KW-0460 | Magnesium |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR013111 | EGF_extracell |
| IPR040622 | I-EGF_1 |
| IPR027071 | Integrin_beta-1 |
| IPR033760 | Integrin_beta_N |
| IPR015812 | Integrin_bsu |
| IPR014836 | Integrin_bsu_cyt_dom |
| IPR012896 | Integrin_bsu_tail |
| IPR036349 | Integrin_bsu_tail_dom_sf |
| IPR002369 | Integrin_bsu_VWA |
| IPR032695 | Integrin_dom_sf |
| IPR016201 | PSI |
| IPR036465 | vWFA_dom_sf |