Gene: ITGB1

Basic information

Tag Content
Uniprot ID A0A452E668
Entrez ID 102178060
Genbank protein ID
Genbank nucleotide ID XM_018056845.1
Ensembl protein ID ENSCHIP00000007476
Ensembl nucleotide ID ENSCHIG00000010934
Gene name Integrin beta
Gene symbol ITGB1
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MHLQLIFWIG LISSVCCVFG QADENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 60
SARCDDLEAL KKKGCHPNDI ENPRGSKDIK KNKNVTNRSK GTAEKLQPED ITQIQPQQLV 120
LQLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180
RIGFGSFVEK TVMPYISTTP AKLRNPCTNE QNCTSPFSYK NVLSLTDKGE VFNELVGKQR 240
ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300
CHLENDVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360
SANSSNVIQL IIDAYNSLSS EVILENSKLP EGVTINYKSY CKNGVNGTGE NGRKCSNISI 420
GDEVQFEISI TANKCPNKNS ETIKIKPLGF TEEVEIILQF ICECECQSEG IPGSPKCHDG 480
NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540
RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTTSCM 600
AVNGQICNGR GVCECGACKC TDPKFQGPTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 660
CAQECSHFNI TKVENRDKLP QPGQVDPLSH CKEKDVDDCW FYFTYSVNGN NEATVHVVET 720
PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 780
PIYKSAVTTV VNPKYEGK 798

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologITGB1102178060A0A452E668Capra hircusPredictionMore>>
1:1 orthologITGB13688P05556Homo sapiensPredictionMore>>
1:1 orthologItgb116412P09055CPOMus musculusPublicationMore>>
1:1 orthologITGB1450396A0A2J8MN19Pan troglodytesPredictionMore>>
1:1 orthologITGB1100008898A0A5F9C3C4Oryctolagus cuniculusPredictionMore>>
1:1 orthologItgb124511A0A0G2JSK5Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0008305 integrin complex
GO:0038023 signaling receptor activity
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0130 Cell adhesion
KW-1015 Disulfide bond
KW-0401 Integrin
KW-0472 Membrane
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013111 EGF_extracell
IPR040622 I-EGF_1
IPR027071 Integrin_beta-1
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS00243 INTEGRIN_BETA

Pfam

Pfam ID Pfam Term
PF07974 EGF_2
PF18372 I-EGF_1
PF08725 Integrin_b_cyt
PF07965 Integrin_B_tail
PF00362 Integrin_beta
PF17205 PSI_integrin