Gene: Dlx5

Basic information

Tag Content
Uniprot ID A0A0G2JSK6
Entrez ID 25431
Genbank protein ID EDM15037.1
Genbank nucleotide ID NM_012943.1
Ensembl protein ID ENSRNOP00000014946
Ensembl nucleotide ID ENSRNOG00000010905
Gene name Distal-less homeobox 5, isoform CRA_a
Gene symbol Dlx5
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTGVFDRRVP SIRSGDFQAP FPTSAAMHHP SQESPTLPES SATDSDYYSP AGAAPHGYCS 60
PTSASYRKAL NPYQYQYHSV NGSAAGYPAK AYADYGYASP YHQYGGAYNR VPSATSQPEK 120
EVAEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 180
VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 240
PTTSNQSPAS SYLENSASWY PSAASSINSH LPPPGSLQHP LALASGTLY 289

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologDLX5507415Q1RMR7Bos taurusPredictionMore>>
1:1 orthologDLX5482313E2RJY3Canis lupus familiarisPredictionMore>>
1:1 orthologDLX5102184778A0A452DYR1Capra hircusPredictionMore>>
1:1 orthologDLX5100052263F7DY45Equus caballusPredictionMore>>
1:1 orthologDLX51749P56178Homo sapiensPredictionMore>>
1:1 orthologDlx513395P70396CPOE13.5Mus musculusPublicationMore>>
1:1 orthologDLX5463554H2QUZ2Pan troglodytesPredictionMore>>
1:1 orthologDLX5A0A287AIX4Sus scrofaPredictionMore>>
1:1 orthologDLX5100008630G1SVH5Oryctolagus cuniculusPredictionMore>>
1:1 orthologDlx525431A0A0G2JSK6Rattus norvegicusPredictionMore>>
1:1 orthologdlx5a30569Q5XJL9Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0000790 nuclear chromatin
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0071837 HMG box domain binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0030509 BMP signaling pathway
GO:0008283 cell population proliferation
GO:0030326 embryonic limb morphogenesis
GO:0001958 endochondral ossification
GO:0030855 epithelial cell differentiation
GO:0060325 face morphogenesis
GO:0042472 inner ear morphogenesis
GO:0097376 interneuron axon guidance
GO:0021889 olfactory bulb interneuron differentiation
GO:0060166 olfactory pit development
GO:0001649 osteoblast differentiation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0050679 positive regulation of epithelial cell proliferation
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0060021 roof of mouth development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR022135 Distal-less_N
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF12413 DLL_N
PF00046 Homeodomain