| Tag | Content |
|---|---|
| Uniprot ID | P70396; O54876; O54877; O54878; Q9JJ45; |
| Entrez ID | 13395 |
| Genbank protein ID | AAC52843.1; AAB94581.1; AAF86636.1; AAB94582.1; AAF86637.1; AAB94580.1; AAB86899.1; |
| Genbank nucleotide ID | NM_010056.3; NM_198854.2; |
| Ensembl protein ID | ENSMUSP00000052559; ENSMUSP00000138264; |
| Ensembl nucleotide ID | ENSMUSG00000029755 |
| Gene name | Homeobox protein DLX-5 |
| Gene symbol | Dlx5 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E13.5 |
| Data sources | Manually collected |
| Reference | 16330189; 19934017; 10433909; 10433912; |
| Functional description | Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. |
| Sequence | MTGVFDRRVP SIRSGDFQAP FPTSAAMHHP SQESPTLPES SATDSDYYSP AGAAPHGYCS 60 PTSASYGKAL NPYQYQYHGV NGSAAGYPAK AYADYGYASP YHQYGGAYNR VPSATSQPEK 120 EVAEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 180 VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 240 PPTSNQSPAS SYLENSASWY PSAASSINSH LPPPGSLQHP LALASGTLY 289 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DLX5 | 507415 | Q1RMR7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | DLX5 | 482313 | E2RJY3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DLX5 | 102184778 | A0A452DYR1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DLX5 | 100052263 | F7DY45 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | DLX5 | 1749 | P56178 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dlx5 | 13395 | P70396 | CPO | E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | DLX5 | 463554 | H2QUZ2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DLX5 | A0A287AIX4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | DLX5 | 100008630 | G1SVH5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Dlx5 | 25431 | A0A0G2JSK6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dlx5a | 30569 | Q5XJL9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA |
| GO:0003677 | DNA binding | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0043565 | sequence-specific DNA binding | IBA |
| GO:0044212 | transcription regulatory region DNA binding | ISO |
| GO:0044212 | transcription regulatory region DNA binding | IDA |
| GO:0071837 | HMG box domain binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001649 | osteoblast differentiation | IDA |
| GO:0001958 | endochondral ossification | IMP |
| GO:0006355 | regulation of transcription, DNA-templated | IMP |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA |
| GO:0007409 | axonogenesis | IMP |
| GO:0007411 | axon guidance | IMP |
| GO:0008283 | cell population proliferation | ISS |
| GO:0008283 | cell population proliferation | ISO |
| GO:0010628 | positive regulation of gene expression | IMP |
| GO:0021889 | olfactory bulb interneuron differentiation | IMP |
| GO:0030154 | cell differentiation | IBA |
| GO:0030326 | embryonic limb morphogenesis | IGI |
| GO:0030509 | BMP signaling pathway | IMP |
| GO:0030855 | epithelial cell differentiation | IGI |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0042472 | inner ear morphogenesis | IGI |
| GO:0043583 | ear development | IMP |
| GO:0045669 | positive regulation of osteoblast differentiation | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0048646 | anatomical structure formation involved in morphogenesis | IGI |
| GO:0048646 | anatomical structure formation involved in morphogenesis | IBA |
| GO:0050679 | positive regulation of epithelial cell proliferation | IGI |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060021 | roof of mouth development | IGI |
| GO:0060166 | olfactory pit development | IMP |
| GO:0060322 | head development | IGI |
| GO:0060325 | face morphogenesis | IMP |
| GO:0060349 | bone morphogenesis | IMP |
| GO:0071773 | cellular response to BMP stimulus | IMP |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IMP |
| GO:0097376 | interneuron axon guidance | IMP |
| GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000790 | nuclear chromatin | IDA |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005737 | cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|